Triamterene
Triamterene structure
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Common Name | Triamterene | ||
|---|---|---|---|---|
| CAS Number | 396-01-0 | Molecular Weight | 253.26300 | |
| Density | 1.502 g/cm3 | Boiling Point | 573.4ºC at 760 mmHg | |
| Molecular Formula | C12H11N7 | Melting Point | 316°C | |
| MSDS | Chinese USA | Flash Point | 11 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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[Clinical strategies for prevention of drug-induced urinary calculi].
Clin. Calcium 21(10) , 1457-63, (2011) Drug-induced urinary calculi, although they account for only 1-2% of urinary calculi, deserve consideration because most of them are preventable. In the drug-containing calculi resulting from the crystallization of a certain drug and its metabolites in the ur... |
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Bioavailability study of triamterene and xipamide using urinary pharmacokinetic data following single oral dose of each drug or their combination.
J. Pharm. Biomed. Anal. 61 , 78-85, (2012) An efficient chromatographic method for the simultaneous determination of triamterene (TRI) and xipamide (XIP) in urine samples, based on high performance liquid chromatography with photodiode array detector (HPLC-DAD) has been developed. The HPLC separation ... |
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Spectrophotometric and spectrodensitometric determination of triamterene and xipamide in pure form and in pharmaceutical formulation.
Drug Test. Anal. 2(3) , 113-21, (2010) Sensitive and validated UV-spectrophotometric, chemometric and TLC-densitometric methods were developed for determination of triamterene (TRM) and xipamide (XIP) in their binary mixture, formulated for use as a diuretic, without previous separation. Method A ... |
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A new resorufin-based alpha-glucosidase assay for high-throughput screening.
Anal. Biochem. 390 , 79-84, (2009) Mutations in alpha-glucosidase cause accumulation of glycogen in lysosomes, resulting in Pompe disease, a lysosomal storage disorder. Small molecule chaperones that bind to enzyme proteins and correct the misfolding and mistrafficking of mutant proteins have ... |
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Use of a rhesus Plasmodium cynomolgi model to screen for anti-hypnozoite activity of pharmaceutical substances.
Am. J. Trop. Med. Hyg. 86(6) , 931-5, (2012) There remains a need for new drugs to prevent relapse of Plasmodium vivax or P. ovale infection. The relapsing primate malaria P. cynomolgi has been used for decades to assess drugs for anti-hypnozoite activity. After sporozoite inoculation and blood-stage cu... |
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Fast quantitative determination of diuretic drugs in tablets and human urine by microchip electrophoresis with native fluorescence detection.
Electrophoresis 28(16) , 2934-41, (2007) Microchip electrophoresis (MCE) with native fluorescence detection has been applied for the fast quantitative analysis of pharmaceutical formulations. For this purpose, methods for fast separation and sensitive detection of the unlabeled diuretic drugs, amilo... |
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Bioequivalence evaluation of a triamterene-hydrochlorothiazide generic product: a new bioequivalence index for fixed-dose combinations.
Regul Toxicol Pharmacol 59(1) , 149-56, (2011) In this study, an open, double-blind, randomized, two-period, two-group crossover design was conducted in 14 healthy volunteers to study the bioequivalence of a fixed-dose generic product. After administration of test or reference products to each volunteer, ... |
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[Pharmacology of potassium-sparing diuretics: amiloride and triamterene].
Coeur Med. Interne 17(2) , 207-15, (1978)
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Dynamics of a heparin-binding domain of VEGF(165) complexed with its inhibitor triamterene.
Biochemistry 50(22) , 4843-54, (2011) Vascular endothelial growth factor (VEGF), which has neurotrophic and neuroprotective effects in addition to its major role in angiogenesis, interacts with Aβ and accumulates in the senile plaques of Alzheimer's disease (AD) patients' brains. It is known that... |
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Design and characterization of a laminar flow-through dissolution apparatus: Comparison of hydrodynamic conditions to those of common dissolution techniques.
Pharm. Dev. Technol. 16(1) , 75-87, (2011) A flow-through dissolution apparatus was designed and evaluated to screen small quantities of pharmaceutical drug compounds early in development. The apparatus was designed to mount on a microscope slide such that a compacted solid drug was positioned flush a... |