Triamterene structure
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Common Name | Triamterene | ||
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CAS Number | 396-01-0 | Molecular Weight | 253.26300 | |
Density | 1.502 g/cm3 | Boiling Point | 573.4ºC at 760 mmHg | |
Molecular Formula | C12H11N7 | Melting Point | 316°C | |
MSDS | Chinese USA | Flash Point | 11 °C | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of TriamtereneTriamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic.Target: Sodium ChannelTriamterene blocked rENaC in a voltage-dependent manner, and was 100-fold less potent than amiloride at pH 7.5. At -90 mV and -40 mV, the IC50 values were 5 microM and 10 microM, respectively. The blockage by triamterene, which is a weak base with a pKa of 6.2, was dependent on the extracellular pH. The IC50 was 1 microM at pH 6.5 and only 17 microM at pH 8.5 [1]. Triamterene (TA) is partly eliminated by a first-pass-effect. The main metabolite of TA is OH-TA-ester, which is pharmacologically active [2]. |
Name | 2,4,7-Triamino-6-Phenylpteridine |
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Synonym | More Synonyms |
Description | Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic.Target: Sodium ChannelTriamterene blocked rENaC in a voltage-dependent manner, and was 100-fold less potent than amiloride at pH 7.5. At -90 mV and -40 mV, the IC50 values were 5 microM and 10 microM, respectively. The blockage by triamterene, which is a weak base with a pKa of 6.2, was dependent on the extracellular pH. The IC50 was 1 microM at pH 6.5 and only 17 microM at pH 8.5 [1]. Triamterene (TA) is partly eliminated by a first-pass-effect. The main metabolite of TA is OH-TA-ester, which is pharmacologically active [2]. |
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Related Catalog | |
References |
Density | 1.502 g/cm3 |
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Boiling Point | 573.4ºC at 760 mmHg |
Melting Point | 316°C |
Molecular Formula | C12H11N7 |
Molecular Weight | 253.26300 |
Flash Point | 11 °C |
Exact Mass | 253.10800 |
PSA | 129.62000 |
LogP | 2.57700 |
Storage condition | 2-8°C |
Water Solubility | <0.1 G/100 ML AT 20 ºC |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302-H315-H319-H335 |
Precautionary Statements | P301 + P312 + P330-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
Hazard Codes | Xn:Harmful; |
Risk Phrases | R22;R36/37/38 |
Safety Phrases | S26-S36/37/39-S45-S33-S24-S16-S7 |
RIDADR | 2811 |
WGK Germany | 3 |
RTECS | UO3470000 |
Packaging Group | III |
Hazard Class | 6.1(b) |
HS Code | 2933990090 |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
[Clinical strategies for prevention of drug-induced urinary calculi].
Clin. Calcium 21(10) , 1457-63, (2011) Drug-induced urinary calculi, although they account for only 1-2% of urinary calculi, deserve consideration because most of them are preventable. In the drug-containing calculi resulting from the crys... |
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Bioavailability study of triamterene and xipamide using urinary pharmacokinetic data following single oral dose of each drug or their combination.
J. Pharm. Biomed. Anal. 61 , 78-85, (2012) An efficient chromatographic method for the simultaneous determination of triamterene (TRI) and xipamide (XIP) in urine samples, based on high performance liquid chromatography with photodiode array d... |
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Spectrophotometric and spectrodensitometric determination of triamterene and xipamide in pure form and in pharmaceutical formulation.
Drug Test. Anal. 2(3) , 113-21, (2010) Sensitive and validated UV-spectrophotometric, chemometric and TLC-densitometric methods were developed for determination of triamterene (TRM) and xipamide (XIP) in their binary mixture, formulated fo... |
Triamterene |
MFCD00006708 |
6-Phenylpteridine-2,4,7-triamine |
2,4,7-Triamino-6-phenylpteridine,6-Phenyl-2,4,7-pteridinetriamine |
EINECS 206-904-3 |
2,4,7-Triamino-6-phenylpteridine 6-Phenyl-2,4,7-pteridinetriamine |