Indoximod
Indoximod structure
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Common Name | Indoximod | ||
|---|---|---|---|---|
| CAS Number | 110117-83-4 | Molecular Weight | 218.252 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 429.3±35.0 °C at 760 mmHg | |
| Molecular Formula | C12H14N2O2 | Melting Point | 242-245 ℃(lit.) | |
| MSDS | Chinese USA | Flash Point | 213.4±25.9 °C | |
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Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs.
Blood 125 , 3905-16, (2015) Although T cells expressing CD19-specific chimeric antigen receptors (CARs) are a promising new therapy for B-cell malignancies, objective responses are observed at lower frequencies in patients with lymphoma than in those with acute B-cell leukemia. We postu... |
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Rational design of indoleamine 2,3-dioxygenase inhibitors.
J. Med. Chem. 53 , 1172-89, (2010) Indoleamine 2,3-dioxygenase (IDO) is an important therapeutic target for the treatment of diseases such as cancer that involve pathological immune escape. We have used the evolutionary docking algorithm EADock to design new inhibitors of this enzyme. First, w... |
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Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy.
J. Immunol. 194 , 5713-24, (2015) Inflammatory kidney disease is a major clinical problem that can result in end-stage renal failure. In this article, we show that Ab-mediated inflammatory kidney injury and renal disease in a mouse nephrotoxic serum nephritis model was inhibited by amino acid... |
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Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation.
J. Immunol. 192(12) , 5548-60, (2014) Caspase-8, an executioner enzyme in the death receptor pathway, was shown to initiate apoptosis and suppress necroptosis. In this study, we identify a novel, cell death-independent role for caspase-8 in dendritic cells (DCs): DC-specific expression of caspase... |
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Inhibition of indoleamine 2,3-dioxygenase activity enhances the anti-tumour effects of a Toll-like receptor 7 agonist in an established cancer model.
Immunology 144(4) , 621-30, (2015) Toll-like receptor (TLR) agonists have been shown to have anti-tumour activity in basic research and clinical studies. However, TLR agonist monotherapy does not sufficiently eliminate tumours. Activation of the innate immune response by TLR agonists is effect... |
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Apoptotic cells induce dendritic cell-mediated suppression via interferon-gamma-induced IDO.
Immunology 124 , 89-101, (2008) Dendritic cells (DC) are sensitive to their local environment and are affected by proximal cell death. This study investigated the modulatory effect of cell death on DC function. Monocyte-derived DC exposed to apoptotic Jurkat or primary T cells failed to ind... |
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The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection.
J. Immunol. 193(6) , 2961-70, (2014) Leishmania (Viannia) parasites are etiological agents of cutaneous leishmaniasis in the New World. Infection is characterized by a mixed Th1/Th2 inflammatory response, which contributes to disease pathology. However, the role of regulatory T cells (Tregs) in ... |
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L-kynurenine/aryl hydrocarbon receptor pathway mediates brain damage after experimental stroke.
Circulation 130(23) , 2040-51, (2014) Aryl hydrocarbon receptor (AhR) is a transcription factor that belongs to the basic helix-loop-helix PAS (Per-Arnt-Sim homology domain) family known to mediate the toxic and carcinogenic effects of xenobiotics. Interestingly, AhR is widely expressed in the ce... |
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Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO.
J. Cancer Res. Clin. Oncol. 140(11) , 1883-90, (2014) Tumor cells have developed multiple mechanisms to escape immune recognition mediated by T cells. Indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme inducing immune tolerance, is involved in tumor escape from host immune systems in mice. Astra... |
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Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.
PLoS Biol. 8 , e1000302, (2010) Immunotherapy using regulatory T cells (Treg) has been proposed, yet cellular and molecular mechanisms of human Tregs remain incompletely characterized. Here, we demonstrate that human Tregs promote the generation of myeloid dendritic cells (DC) with reduced ... |