WR-1065
WR-1065 structure
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Common Name | WR-1065 | ||
|---|---|---|---|---|
| CAS Number | 14653-77-1 | Molecular Weight | 207.16 | |
| Density | 0.975g/cm3 | Boiling Point | 218.6ºC at 760 mmHg | |
| Molecular Formula | C5H16Cl2N2S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 86ºC | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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A manganese superoxide dismutase (SOD2)-mediated adaptive response.
Radiat. Res. 179(2) , 115-24, (2013) Very low doses of ionizing radiation, 5 to 100 mGy, can induce adaptive responses characterized by elevation in cell survival and reduction in micronuclei formation. Utilizing these end points, RKO human colon carcinoma and transformed mouse embryo fibroblast... |
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Aminothiol WR1065 induces differential gene expression in the presence of wild-type p53.
Oncogene 24(24) , 3964-75, (2005) The aminothiol WR1065 exerts selective cytoprotective effects in normal cells compared to cancer cells and has clinical applications for the protection of normal cells in cancer patients undergoing radio- or chemotherapy. There is evidence that p53 is activat... |
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Clinical pharmacokinetics of amifostine and WR1065 in pediatric patients with medulloblastoma.
Clin. Cancer Res. 16(3) , 1049-57, (2010) We evaluated the pharmacokinetics of amifostine and WR1065 in pediatric patients with newly diagnosed medulloblastoma to assess the influence of patient covariates, including demographics, clinical characteristics, and genetic polymorphisms, on amifostine and... |
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WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication.
Environ. Mol. Mutagen. 50(6) , 460-72, (2009) The success of nucleoside reverse transcriptase inhibitors (NRTIs) in treating HIV-1 infection and reducing mother-to-child transmission of the virus during pregnancy is accompanied by evidence that NRTIs cause long-term health risks for cancer and mitochondr... |
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Inhibition of human sperm respiration by 4-hydroperoxycyclophosphamide and protection by mesna and WR-1065
Fertil. Steril. 91(1) , 173-8, (2009) Objective To determine the effect of 4-hydroperoxycyclophosphamide (4OOH-CP) on the respiration of human sperm, and investigate the protective properties of mesna and WR-1065. |
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Radioprotective effect of American ginseng on human lymphocytes at 90 minutes postirradiation: a study of 40 cases.
J. Altern. Complement. Med. 16(5) , 561-7, (2010) Ionizing radiation (IR) initiates intracellular oxidative stress through enhanced formation of reactive oxygen species (ROS) that attack DNA leading to cell death. Because of the diversity of IR applied in medicine, agriculture, industry, and the growing thre... |
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Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells.
Radiat. Res. 173(2) , 175-83, (2010) Repair of DNA damage through homologous recombination (HR) pathways plays a crucial role in maintaining genome stability. However, overstimulation of HR pathways in response to genotoxic stress may abnormally elevate recombination frequencies, leading to incr... |
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Yeast DEL assay detects protection against radiation-induced cytotoxicity and genotoxicity: adaptation of a microtiter plate version.
Radiat. Res. 174(6) , 719-26, (2010) The DEL assay in yeast detects DNA deletions that are inducible by many carcinogens. Here we use the colorimetric agent MTS to adapt the yeast DEL assay for microwell plate measurement of ionizing radiation-induced cell killing and DNA deletions. Using the mi... |
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Determination of WR-1065 in human blood by high-performance liquid chromatography following fluorescent derivatization by a maleimide reagent ThioGlo3.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 819(1) , 161-7, (2005) In order to improve the sensitivity and stability of human blood samples containing WR-1065 (i.e., active metabolite of the cytoprotective agent amifostine), a high-performance liquid chromatographic method was developed and validated using fluorescent deriva... |
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Effect of North American ginseng on 137Cs-induced micronuclei in human lymphocytes: a comparison with WR-1065.
Phytother Res. 22(12) , 1614-22, (2008) To explore the radioprotective effect of a standardized North American ginseng extract (NAGE) on human peripheral blood lymphocytes (PBL), a micronuclei (MN) assay was conducted in PBL obtained from 12 volunteers. NAGE (50-1000 microg/mL) and WR-1065 (1 mM an... |