ponasterone A
ponasterone A structure
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Common Name | ponasterone A | ||
|---|---|---|---|---|
| CAS Number | 13408-56-5 | Molecular Weight | 464.635 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 640.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C27H44O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 355.2±28.0 °C | |
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Endogenous CCL2 neutralization restricts HIV-1 replication in primary human macrophages by inhibiting viral DNA accumulation.
Retrovirology 12 , 4, (2015) Macrophages are key targets of HIV-1 infection. We have previously described that the expression of CC chemokine ligand 2 (CCL2) increases during monocyte differentiation to macrophages and it is further up-modulated by HIV-1 exposure. Moreover, CCL2 acts as ... |
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A single-residue change in the HIV-1 V3 loop associated with maraviroc resistance impairs CCR5 binding affinity while increasing replicative capacity.
Retrovirology 12 , 50, (2015) Maraviroc (MVC) is an allosteric CCR5 inhibitor used against HIV-1 infection. While MVC-resistant viruses have been identified in patients, it still remains incompletely known how they adjust their CD4 and CCR5 binding properties to resist MVC inhibition whil... |
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Genome-wide promoter binding profiling of protein phosphatase-1 and its major nuclear targeting subunits.
Nucleic Acids Res. 43 , 5771-84, (2015) Protein phosphatase-1 (PP1) is a key regulator of transcription and is targeted to promoter regions via associated proteins. However, the chromatin binding sites of PP1 have never been studied in a systematic and genome-wide manner. Methylation-based DamID pr... |
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Biochemical, histological and functional correction of mucopolysaccharidosis type IIIB by intra-cerebrospinal fluid gene therapy.
Hum. Mol. Genet. 24(7) , 2078-95, (2015) Gene therapy is an attractive tool for the treatment of monogenic disorders, in particular for lysosomal storage diseases (LSD) caused by deficiencies in secretable lysosomal enzymes in which neither full restoration of normal enzymatic activity nor transduct... |
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Binding of GTPgamma[35S] is regulated by GDP and receptor activation. Studies with the nociceptin/orphanin FQ receptor.
Br. J. Pharmacol. 159(6) , 1286-93, (2010) We have examined the effects of ligand efficacy and receptor density on the binding of guanosine 5'-[gamma-thio]triphosphate (GTPgammaS) and GDP to the nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP)-coupled G-proteins.In GTPgamma[(35)S] binding experim... |
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Indoxyl sulfate induces oxidative stress and hypertrophy in cardiomyocytes by inhibiting the AMPK/UCP2 signaling pathway.
Toxicol. Lett. 234(2) , 110-9, (2015) As a typical protein-bound uremic toxin, indoxyl sulfate is considered to be able to induce cardiomyocytes hypertrophy by promoting oxidative stress in chronic kidney disease (CKD). Uncoupling protein 2 (UCP2), a member of the uncoupling protein family, may p... |
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Ecdysteroid receptor from the American lobster Homarus americanus: EcR/RXR isoform cloning and ligand-binding properties.
Gen. Comp. Endocrinol. 173(2) , 346-55, (2011) In arthropods, ecdysteroids regulate molting by activating a heterodimer formed by the ecdysone receptor (EcR) and retinoid X receptor (RXR). While this mechanism is similar in insects and crustaceans, variation in receptor splicing, dimerization and ligand a... |
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Quantification of ecdysteroids and retinoic acids in whole daphnids by liquid chromatography-triple quadrupole mass spectrometry.
J. Chromatogr. A. 1438 , 57-64, (2016) Quantification of ecdysteroids and retinoic acids at picograms per individual is typically achieved with radioimmunoassay methods. However, those methods cannot identify individual types of ecdysteroids or provide an absolute concentration, which poses proble... |
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Reconfigurable hybrid interface for molecular marker diagnostics and in-situ reporting.
Biosens. Bioelectron. 74 , 744-50, (2015) Combinations of molecular signals such as transcription factors and microRNAs in cells are a reliable indicator of multi-gene disorders. A system capable of detecting these conditions in-situ may be used as a tool for diagnosis and monitoring of disease. Here... |
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Cloning, ligand-binding, and temporal expression of ecdysteroid receptors in the diamondback moth, Plutella xylostella.
BMC Mol. Biol. 13 , 32, (2012) The diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae), is a devastating pest of cruciferous crops worldwide, and has developed resistance to a wide range of insecticides, including diacylhydrazine-based ecdysone agonists, a highly selectiv... |