diazoxide
diazoxide structure
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Common Name | diazoxide | ||
|---|---|---|---|---|
| CAS Number | 364-98-7 | Molecular Weight | 230.671 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 414.8±47.0 °C at 760 mmHg | |
| Molecular Formula | C8H7ClN2O2S | Melting Point | >310°C | |
| MSDS | Chinese USA | Flash Point | 204.6±29.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Magnesium isoglycyrrhizinate protects hepatic L02 cells from ischemia/reperfusion induced injury.
Int. J. Clin. Exp. Pathol. 7(8) , 4755-64, (2014) Human liver ischemia/reperfusion injury (IRI) is a common and major clinical problem complicating liver surgery and transplantation. The pathogenesis underlying IRI is complex, involving a series of signaling mediators and mechanisms. This study aimed to inve... |
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Accelerated recovery of mitochondrial membrane potential by GSK-3β inactivation affords cardiomyocytes protection from oxidant-induced necrosis.
PLoS ONE 9(11) , e112529, (2014) Loss of mitochondrial membrane potential (ΔΨm) is known to be closely linked to cell death by various insults. However, whether acceleration of the ΔΨm recovery process prevents cell necrosis remains unclear. Here we examined the hypothesis that facilitated r... |
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ATP-sensitive potassium (K(ATP)) channel openers diazoxide and nicorandil lower intraocular pressure in vivo.
Invest. Ophthalmol. Vis. Sci. 54(7) , 4892-9, (2013) To evaluate the expression of ATP-sensitive potassium (K(ATP)) channel subunits and study the effect of K(ATP) channel openers diazoxide and nicorandil on intraocular pressure (IOP) in an in vivo mouse model.Expression of K(ATP) channel subunits in normal C57... |
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Glucose Induces Slow-Wave Sleep by Exciting the Sleep-Promoting Neurons in the Ventrolateral Preoptic Nucleus: A New Link between Sleep and Metabolism.
J. Neurosci. 35 , 9900-11, (2015) Sleep-active neurons located in the ventrolateral preoptic nucleus (VLPO) play a crucial role in the induction and maintenance of slow-wave sleep (SWS). However, the cellular and molecular mechanisms responsible for their activation at sleep onset remain poor... |
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Adenosine Triphosphate-Sensitive Potassium Channel Kir Subunits Implicated in Cardioprotection by Diazoxide.
J. Am. Heart Assoc. 4 , e002016, (2015) ATP-sensitive potassium (K(ATP)) channel openers provide cardioprotection in multiple models. Ion flux at an unidentified mitochondrial K(ATP) channel has been proposed as the mechanism. The renal outer medullary kidney potassium channel subunit, potassium in... |
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Low glucose-induced ghrelin secretion is mediated by an ATP-sensitive potassium channel.
J. Endocrinol. 226 , 25-34, (2015) Ghrelin is synthesized in X/A-like cells of the gastric mucosa, which plays an important role in the regulation of energy homeostasis. Although ghrelin secretion is known to be induced by neurotransmitters or hormones or by nutrient sensing in the ghrelin-sec... |
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Po2 cycling protects diaphragm function during reoxygenation via ROS, Akt, ERK, and mitochondrial channels.
Am. J. Physiol. Cell Physiol. 309 , C759-66, (2015) Po2 cycling, often referred to as intermittent hypoxia, involves exposing tissues to brief cycles of low oxygen environments immediately followed by hyperoxic conditions. After experiencing long-term hypoxia, muscle can be damaged during the subsequent reintr... |
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Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(1) , R35-43, (2014) β-mercaptoacetate (MA) is a drug known to block mitochondrial oxidation of medium- and long-chain fatty acids (FAs) and to stimulate feeding. Because MA-induced feeding is vagally dependent, it has been assumed that the feeding response is mediated by MA's an... |
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Ca(2+) clearance by plasmalemmal NCLX, Li(+)-permeable Na(+)/Ca(2+) exchanger, is required for the sustained exocytosis in rat insulinoma INS-1 cells.
Pflugers Arch. 467 , 2461-72, (2015) Na(+)/Ca(2+) exchangers are key players for Ca(2+) clearance in pancreatic β-cells, but their molecular determinants and roles in insulin secretion are not fully understood. In the present study, we newly discovered that the Li(+)-permeable Na(+)/Ca(2+) excha... |
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Cardioprotective benefits of adenosine triphosphate-sensitive potassium channel opener diazoxide are lost with administration after the onset of stress in mouse and human myocytes.
J. Am. Coll. Surg. 219(4) , 803-13, (2014) Adenosine triphosphate-sensitive (KATP) potassium channel opener diazoxide (DZX) maintains myocyte volume and contractility during stress via an unknown mechanism when administered at the onset of stress. This study was performed to investigate the cardioprot... |