N-Allylnormetazocine hydrochloride
N-Allylnormetazocine hydrochloride structure
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Common Name | N-Allylnormetazocine hydrochloride | ||
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| CAS Number | 133005-41-1 | Molecular Weight | 293.83200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H24ClNO | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Allosteric modulation of sigma-1 receptors elicits anti-seizure activities.
Br. J. Pharmacol. 172 , 4052-65, (2015) Application of orthosteric sigma-1 receptor agonists as anti-seizure drugs has been hindered by questionable efficacy and potential adverse effects. Here, we have investigated the anti-seizure effects of the novel and potent allosteric modulator of sigma-1 re... |
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Sigma1 recognition sites in rabbit iris-ciliary body: topical sigma1-site agonists lower intraocular pressure.
J. Pharmacol. Exp. Ther. 289 , 1362, (1999) In this study, we examined the presence of sigma1 and sigma2 sites in the rabbit iris-ciliary body by receptor binding and investigated their effects on intraocular pressure (IOP) in albino rabbits. The iris-ciliary body has binding sites for the sigma1-site ... |
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sigma receptor ligands attenuate N-methyl-D-aspartate cytotoxicity in dopaminergic neurons of mesencephalic slice cultures.
Eur. J. Pharmacol. 388 , 139-146, (2000) We investigated the potential neuroprotective effects of several sigma receptor ligands in organotypic midbrain slice cultures as an excitotoxicity model system. When challenged with 100-microM N-methyl-D-aspartate (NMDA) for 24 h, dopaminergic neurons in mid... |
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Pharmacological specificity of some psychotomimetic and antipsychotic agents for the sigma and PCP binding sites.
Life Sci. 42 , 745, (1988) The pharmacological specificity of representative psychotomimetic agents such as phencyclidine (PCP) analogs, opiate benzomorphans and several antipsychotic agents was assessed for the sigma and PCP binding sites. In a series of binding experiments, in rat br... |
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Basal bioenergetic abnormalities in skeletal muscle from ryanodine receptor malignant hyperthermia-susceptible R163C knock-in mice.
J. Thorac. Cardiovasc. Surg. 286 , 99-113, (2011) Malignant hyperthermia (MH) and central core disease in humans have been associated with mutations in the skeletal ryanodine receptor (RyR1). Heterozygous mice expressing the human MH/central core disease RyR1 R163C mutation exhibit MH when exposed to halotha... |
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Sigma receptor photolabeling and sigma receptor-mediated modulation of potassium channels in tumor cells.
J. Biol. Chem. 274 , 18387-18392, (1999) Recent work has indicated that sigma receptor ligands can modulate potassium channels. However, the only sigma receptor characterized at the molecular level has a novel structure unlike any other receptor known to modulate ion channels. This 26-kDa protein ha... |
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Pharmacological profiles of opioid ligands at kappa opioid receptors.
BMC Pharmacol. 6 , 3, (2006) The aim of the present study was to describe the activity of a set of opioid drugs, including partial agonists, in a human embryonic kidney cell system stably expressing only the mouse kappa-opioid receptors. Receptor activation was assessed by measuring the ... |
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Activity of opioid ligands in cells expressing cloned mu opioid receptors.
BMC Pharmacol. 3 , 1, (2003) The aim of the present study was to describe the activity of a set of opioid drugs, including partial agonists, in a cell system expressing only mu opioid receptors. Receptor activation was assessed by measuring the inhibition of forskolin-stimulated cyclic a... |
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Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands.
Br. J. Pharmacol. 168 , 1445-55, (2013) The Sigma-1 receptor (Sig1R) impacts on calcium ion signalling and has a plethora of ligands. This study investigated Sig1R and its ligands in relation to endogenous calcium events of endothelial cells and transient receptor potential (TRP) channels.Intracell... |
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Activation profiles of opioid ligands in HEK cells expressing delta opioid receptors.
BMC Neurosci. 3 , 19, (2003) The aim of the present study was to characterize the activation profiles of 15 opioid ligands in transfected human embryonic kidney cells expressing only delta opioid receptors. Activation profiles of most of these ligands at delta opioid receptors had not be... |