133005-41-1
133005-41-1 structure
- Name: N-Allylnormetazocine hydrochloride
- Chemical Name: (+)-N-Allyl Normetazocine Hydrochloride
- CAS Number: 133005-41-1
- Molecular Formula: C17H24ClNO
- Molecular Weight: 293.83200
- Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
- Create Date: 2016-11-22 15:58:59
- Modify Date: 2025-08-25 09:41:40
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(+)-N-Allylnormetazocine ((+)-SKF 10047) hydrochloride is a benzomorphan opioid with psychotomi metic effects. (+)-N-Allylnormetazocine hydrochloride is an opioid receptor antagonist with Ki values of 300 nM and 27 μM for σ1 and σ2 opioid receptors, respectively. (+)-N-Allylnormetazocine hydrochloride can be used for the research of neurological disease[1][2].
| Name | (+)-N-Allyl Normetazocine Hydrochloride |
|---|---|
| Synonyms | (+)-N-Allylnormetazocine hydrochloride |
| Description | (+)-N-Allylnormetazocine ((+)-SKF 10047) hydrochloride is a benzomorphan opioid with psychotomi metic effects. (+)-N-Allylnormetazocine hydrochloride is an opioid receptor antagonist with Ki values of 300 nM and 27 μM for σ1 and σ2 opioid receptors, respectively. (+)-N-Allylnormetazocine hydrochloride can be used for the research of neurological disease[1][2]. |
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| Related Catalog | |
| In Vitro | (+)-N-Allylnormetazocine hydrochloride (1 nM) 对 µ，δ 和 κ 阿片受体的抑制率分别为 28.5%，2.5% 和 31%[1]。 (+)-N-Allylnormetazocine hydrochloride 对 σ1 和 σ2 阿片受体的 Ki 值分别为 300 nM 和 27 μM[1]。 |
| In Vivo | (+)-N-Allylnormetazocine hydrochloride (0.3，1，3，10 和 30 mg/kg；腹腔注射，每次实验前10 分钟) 剂量依赖性地增加解离性麻醉药苯环利定 (PCP) 的反应[2]。 |
| References |
| Molecular Formula | C17H24ClNO |
|---|---|
| Molecular Weight | 293.83200 |
| Exact Mass | 293.15500 |
| PSA | 23.47000 |
| LogP | 3.84230 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |