Calyculin A
Calyculin A structure
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Common Name | Calyculin A | ||
|---|---|---|---|---|
| CAS Number | 101932-71-2 | Molecular Weight | 1009.17000 | |
| Density | 1.25g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C50H81N4O15P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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A novel receptor cross-talk between the ATP receptor P2Y2 and formyl peptide receptors reactivates desensitized neutrophils to produce superoxide
Exp. Cell Res. 323(1) , 209-17, (2014) Neutrophils express several G-protein coupled receptors (GPCRs) and they cross regulate each other. We described a novel cross-talk mechanism in neutrophils, by which signals generated by the receptor for ATP (P2Y2) reactivate desensitized formyl peptide rece... |
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Detachment-induced autophagy in three-dimensional epithelial cell cultures.
Meth. Enzymol. 452 , 423-39, (2009) Integrin-mediated cell adhesion to extracellular matrix (ECM) is critical for normal epithelial cell survival; cells deprived of ECM contact rapidly undergo apoptotic cell death, termed anoikis. Recent work demonstrates that ECM detachment also robustly induc... |
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Unique features of the okadaic acid activity class of tumor promoters.
J. Cancer Res. Clin. Oncol. 125 , 150-155, (1999) Following the first report of tumor promotion by okadaic acid in 1988, we further identified additional tumor promoters of the okadaic acid activity class, such as calyculin A and microcystin-LR. However, tautomycin, which is also an inhibitor of protein phos... |
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γ-Aminobutyric acid type A (GABAA) receptor activation modulates tau phosphorylation.
J. Biol. Chem. 287(9) , 6743-52, (2012) Abnormal phosphorylation and aggregation of the microtubule-associated protein Tau are hallmarks of various neurodegenerative diseases, such as Alzheimer disease. Molecular mechanisms that regulate Tau phosphorylation are complex and currently incompletely un... |
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Traction force microscopy in rapidly moving cells reveals separate roles for ROCK and MLCK in the mechanics of retraction.
Exp. Cell Res. 326(2) , 280-94, (2014) Retraction is a major rate-limiting step in cell motility, particularly in slow moving cell types that form large stable adhesions. Myosin II dependent contractile forces are thought to facilitate detachment by physically pulling up the rear edge. However, re... |
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Cytoskeleton reorganization as an alternative mechanism of store-operated calcium entry control in neuroendocrine-differentiated cells.
PLoS ONE 7(9) , e45615, (2012) Neuroendocrine differentiation (NED) is a hallmark of advanced androgen-independent prostate cancer, for which no successful therapy exists. NED tumour cells escape apoptotic cell death by alterations of Ca(2+) homeostasis where the store-operated Ca(2+) entr... |
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Clofibrate relaxes the longitudinal smooth muscle of the mouse distal colon through calcium-mediated desensitisation of contractile machinery.
Pharmacology 88(1-2) , 65-71, (2011) Peroxisome proliferator-activated receptor α (PPAR-α) is a ligand-activated transcription factor that exerts strong effects on metabolic pathways. Our aim was to elucidate the effect of clofibrate, a PPAR-α agonist, on the longitudinal muscle of the mouse dis... |
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An integrated platform of genomic assays reveals small-molecule bioactivities.
Nat. Chem. Biol. 4 , 498-506, (2008) Bioactive compounds are widely used to modulate protein function and can serve as important leads for drug development. Identifying the in vivo targets of these compounds remains a challenge. Using yeast, we integrated three genome-wide gene-dosage assays to ... |
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Mode-specific inhibition of sodium-calcium exchange during protein phosphatase blockade.
J. Biol. Chem. 274 , 33279-33286, (1999) The effects of the protein phosphatase inhibitors calyculin A and okadaic acid on Na(+)/Ca(2+) exchange activity were examined in transfected Chinese hamster ovary cells expressing the bovine cardiac Na(+)/Ca(2+) exchanger. Incubating the cells for 5-10 min w... |
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A major role for the rho-associated coiled coil forming protein kinase in G-protein-mediated Ca2+ sensitization through inhibition of myosin phosphatase in rabbit trachea.
Br. J. Pharmacol. 128 , 925-933, (1999) 1 G protein-mediated Ca2+ sensitization of airway smooth muscle contraction was investigated with respect to the relative importance of Rho-associated coiled coil forming protein kinase (ROCK) and protein kinase C (PKC). We examined the effects of Y-27632, a ... |