17-ODYA
17-ODYA structure
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Common Name | 17-ODYA | ||
|---|---|---|---|---|
| CAS Number | 34450-18-5 | Molecular Weight | 280.445 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 400.8±18.0 °C at 760 mmHg | |
| Molecular Formula | C18H32O2 | Melting Point | 142-148 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 194.7±15.9 °C | |
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Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.
Proteomics 15 , 2066-77, (2015) Protein acylation plays a critical role in protein localization and function. Acylation is essential for human immunodeficiency virus 1 (HIV-1) assembly and budding of HIV-1 from the plasma membrane in lipid raft microdomains and is mediated by myristoylation... |
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Interaction of epoxyeicosatrienoic acids and adipocyte fatty acid-binding protein in the modulation of cardiomyocyte contractility.
Int. J. Obes. 39 , 755-61, (2015) Adipocyte fatty acid-binding protein (FABP4) is a member of a highly conserved family of cytosolic proteins that bind with high affinity to hydrophobic ligands, such as saturated and unsaturated long-chain fatty acids and eicosanoids. Recent evidence has supp... |
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Species differences in intestinal metabolic activities of cytochrome P450 isoforms between cynomolgus monkeys and humans.
Drug Metab. Pharmacokinet. 26(3) , 300-6, (2011) The oral bioavailability of some drugs is markedly lower in cynomolgus monkeys than in humans. One of the reasons for the low bioavailability in cynomolgus monkeys may be the higher metabolic activity of intestinal CYP3A; however, the species differences in i... |
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Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential.
J. Lipid Res. 55(12) , 2479-90, (2014) Arachidonic acid (AA) is a major PUFA that has been implicated in the regulation of adipogenesis. We examined the effect of a short exposure to AA at different stages of 3T3-L1 adipocyte differentiation. AA caused the upregulation of fatty acid binding protei... |
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Changes in renal haemodynamics induced by indomethacin in the rat involve cytochrome P450 arachidonic acid-dependent epoxygenases.
Clin. Exp. Pharmacol. Physiol. 31(10) , 683-90, (2004) A significant renal vasodilation was observed previously after an acute cyclo-oxygenase (COX) inhibition induced with indomethacin. Because this effect could be due to COX-dependent intrarenal metabolization of arachidonic acid through cytochrome P450 (CYP450... |
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17-Octadecynoic acid improves contractile response to angiotensin II by releasing vasocontrictor prostaglandins.
Prostaglandins Other Lipid Mediat. 97(1-2) , 36-42, (2012) The present study investigated the role of CYP-enzymes in the modulation of vasoconstrictor responses to angiotensin II in rabbit aortae. In arteries with the endothelium-intact (E+) the CYP-inhibitor, 17-octadecynoic acid (17 ODYA), increased the efficacy to... |
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P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells.
J. Huazhong Univ. Sci. Technolog. Med. Sci. 31(5) , 596-601, (2011) P-450-dependent epoxygenase pathway of arachidonic acid and the products of epoxyeicosatrienoic acids (EETs) have been demonstrated to be involved in angiogenesis and tumor progression. This study examined the expression of EETs and the role of the pathway in... |
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Role of 20-HETE in the hypoxia-induced activation of Ca2+-activated K+ channel currents in rat cerebral arterial muscle cells.
Am. J. Physiol. Heart Circ. Physiol. 294(1) , H107-20, (2008) The mechanism of sensing hypoxia and hypoxia-induced activation of cerebral arterial Ca(2+)-activated K(+) (K(Ca)) channel currents and vasodilation is not known. We investigated the roles of the cytochrome P-450 4A (CYP 4A) omega-hydroxylase metabolite of ar... |
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Bioorthogonal proteomics of 15-hexadecynyloxyacetic acid chemical reporter reveals preferential targeting of fatty acid modified proteins and biosynthetic enzymes.
Bioorg. Med. Chem. 20(2) , 650-4, (2012) Chemical reporters are powerful tools for the detection and discovery of protein modifications following cellular labeling. The metabolism of alkyne- or azide-functionalized chemical reporters in cells can influence the efficiency and specificity of protein t... |
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Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine.
Drug Metab. Dispos. 35(11) , 2067-75, (2007) CYP4F enzymes, including CYP4F2 and CYP4F3B, were recently shown to be the major enzymes catalyzing the initial oxidative O-demethylation of the antiparasitic prodrug pafuramidine (DB289) by human liver microsomes. As suggested by a low oral bioavailability, ... |