FGIN-1-27
FGIN-1-27 structure
|
Common Name | FGIN-1-27 | ||
|---|---|---|---|---|
| CAS Number | 142720-24-9 | Molecular Weight | 436.60500 | |
| Density | 1.073g/cm3 | Boiling Point | 608.3ºC at 760mmHg | |
| Molecular Formula | C28H37FN2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 321.7ºC | |
|
Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands.
Bioorg. Med. Chem. 12(2) , 423-38, (2004) Since the peripheral benzodiazepine receptor (PBR) has been primarily found as a high-affinity binding site for diazepam in rat kidney, numerous studies of it have been performed. However, the physiological role and functions of PBR have not been fully elucid... |
|
|
Translocator protein (18 kDa) as a pharmacological target in adipocytes to regulate glucose homeostasis.
Biochem. Pharmacol. 97 , 99-110, (2015) As a major regulator in obesity and its associated metabolic complications, the proper functioning of adipocytes is crucial for health maintenance, thus serving as an important target for the development of anti-obese and anti-diabetic therapies. There is inc... |
|
|
Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway.
Br. J. Cancer 89(3) , 564-72, (2003) Specific ligands of the peripheral benzodiazepine receptor (PBR) are known to induce apoptosis and cell cycle arrest in oesophageal cancer cells. However, the underlying mechanisms are still unknown. Here, we investigated the transcriptional alterations and a... |
|
|
Enhancement of peripheral benzodiazepine receptor ligand-induced apoptosis and cell cycle arrest of esophageal cancer cells by simultaneous inhibition of MAPK/ERK kinase.
Biochem. Pharmacol. 67(9) , 1701-10, (2004) Specific ligands of the peripheral benzodiazepine receptor (PBR) activate pro-apoptotic and anti-proliferative signaling pathways. Previously, we found that PBR ligands activated the p38 mitogen-activated protein kinase (MAPK) pathway in esophageal cancer cel... |
|
|
Preparation of indoles from alpha-aminonitriles: A short synthesis of FGIN-1-27.
Org. Lett. 8(20) , 4473-5, (2006) Alpha-Aminonitriles derived from 2-aminocinnamic acid esters and amides can be cyclized under basic conditions to furnish substituted indole-3-acetic acid derivatives in quantitative yield. The reaction provides a simple access to a class of biologically acti... |
|
|
Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR).
Toxicol. Lett. 202(2) , 148-54, (2011) Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) regulate xenobiotic sensing and metabolism through interactions with multiple exogenous and endogenous chemicals. Compounds that activate CAR are often ligands of PXR; attention is therefore... |
|
|
In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters.
Psychopharmacology 178(2-3) , 174-82, (2005) There are two types of benzodiazepine receptors, mitochondrial benzodiazepine receptors (MBRs), and gamma-aminobutyric acid (GABA(A))/benzodiazepine receptor complexes (GBRs). MBR activation increases neurosteroidogenesis. Ventral tegmental area (VTA) infusio... |
|
|
Effects of neurosteroid actions at N-methyl-D-aspartate and GABA A receptors in the midbrain ventral tegmental area for anxiety-like and mating behavior of female rats.
Psychopharmacology 213(1) , 93-103, (2011) In the midbrain ventral tegmental area (VTA), actions of neurosteroids, such as the progesterone metabolite, 5α-pregnan-3α-ol-20-one (3α,5α-THP), can facilitate mating and influence stress-related processes. Some actions of 3α,5α-THP may occur via positive mo... |
|
|
Mitochondrial benzodiazepine receptors regulate oxygen homeostasis in the early mouse embryo.
Reprod. Toxicol. 17(4) , 365-75, (2003) The peripheral benzodiazepine receptor (Bzrp) has been implicated in the control of several processes, including mitochondrial biogenesis and embryo development. The present study examined the impact that specific Bzrp ligands have on oxygen homeostasis in th... |
|
|
Mitochondrial benzodiazepine receptors in the ventral tegmental area modulate sexual behaviour of cycling or hormone-primed hamsters.
J. Neuroendocrinol. 15(7) , 677-86, (2003) Hamsters are highly dependent upon the central actions of progesterone (P4) for facilitation of sexual behaviour. In the ventral tegmental area (VTA), P4 has actions through its neurosteroid metabolite 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP). The ... |