Organic Letters 2006-09-28

Preparation of indoles from alpha-aminonitriles: A short synthesis of FGIN-1-27.

Till Opatz, Dorota Ferenc

Index: Org. Lett. 8(20) , 4473-5, (2006)

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Abstract

Alpha-Aminonitriles derived from 2-aminocinnamic acid esters and amides can be cyclized under basic conditions to furnish substituted indole-3-acetic acid derivatives in quantitative yield. The reaction provides a simple access to a class of biologically active compounds.