Devazepide
Devazepide structure
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Common Name | Devazepide | ||
|---|---|---|---|---|
| CAS Number | 103420-77-5 | Molecular Weight | 408.45200 | |
| Density | 1.31g/cm3 | Boiling Point | 758.6ºC at 760mmHg | |
| Molecular Formula | C25H20N4O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 412.6ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Ongoing ingestive behavior is rapidly suppressed by a preabsorptive, intestinal "bitter taste" cue.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 301(5) , R1557-68, (2011) The discovery that cells in the gastrointestinal (GI) tract express the same molecular receptors and intracellular signaling components known to be involved in taste has generated great interest in potential functions of such post-oral "taste" receptors in th... |
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Behavioral and cortical EEG evaluations confirm the roles of both CCKA and CCKB receptors in mouse CCK-induced anxiety.
Behav. Brain Res. 237 , 325-32, (2013) This study investigated the roles of cholecystokinin (CCK)(A) and CCK(B) receptors on CCK-4-induced anxiety-like behaviors in mice through behavioral and neural evaluations. Anxiety-like behaviors in mice were induced by an intracerebroventricular (i.c.v.) ad... |
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Synergistic effect of CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin on food intake regulation in lean mice.
BMC Neurosci. 9 , 101, (2008) CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin (CCK) are neuromodulators involved in feeding behavior. This study is based on previously found synergistic effect of leptin and CCK on food intake and our hypothesis on a co-ope... |
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Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line.
Pancreas 39(2) , 127-34, (2010) This study evaluated the role played by cholecystokinin (CCK) receptors' occupation in the control of somatostatin (SS) secretion in RIN-14B cells.The presence of the CCK receptors 1 and 2 was confirmed by immunofluorescence, and SS secretion was evaluated by... |
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Devazepide, a nonpeptide antagonist of CCK receptors, induces apoptosis and inhibits Ewing tumor growth.
Anticancer Drugs 20(7) , 527-33, (2009) The Ewing family of tumors is a group of highly malignant tumors that mainly arise in bone and most often affect children and young adults in the first two decades of life. Despite the use of multimodal therapy, the long-term disease-free survival rate of pat... |
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Lipid-enriched enteral nutrition controls the inflammatory response in murine Gram-negative sepsis.
Crit. Care Med. 38(10) , 1996-2002, (2010) Controlling the inflammatory cascade during sepsis remains a major clinical challenge. Recently, it has become evident that the autonomic nervous system reduces inflammation through the vagus nerve. The current study investigates whether nutritional stimulati... |
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Effects of exogenous cholecystokinin octapeptide on acquisition of naloxone precipitated withdrawal induced conditioned place aversion in rats.
PLoS ONE 7(7) , e41860, (2012) Cholecystokinin octapeptide (CCK-8), a gut-brain peptide, regulates a variety of physiological behavioral processes. Previously, we reported that exogenous CCK-8 attenuated morphine-induced conditioned place preference, but the possible effects of CCK-8 on av... |
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Alterations in activity and energy expenditure contribute to lean phenotype in Fischer 344 rats lacking the cholecystokinin-1 receptor gene.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 303(12) , R1231-40, (2012) CCK is hypothesized to inhibit meal size by acting at CCK1 receptors (CCK1R) on vagal afferent neurons that innervate the gastrointestinal tract and project to the hindbrain. Earlier studies have shown that obese Otsuka Long-Evans Tokushima Fatty (OLETF) rats... |
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The trophic effect of cholecystokinin on the pancreas declines in rats on total parenteral nutrition.
J. Anim. Physiol. Anim. Nutr. (Berl.) 96(2) , 214-9, (2012) Total parenteral nutrition (TPN) results in atrophy of the pancreas, while cholecystokinin (CCK) can significantly stimulate the exocrine pancreas in rodents. This study was designed to examine whether CCK may improve the atrophy of the pancreas in rats on TP... |
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Ileal interposition attenuates the satiety responses evoked by cholecystokinin-8 and -33.
Peptides 32(6) , 1296-302, (2011) One of the possible mechanisms by which the weight-reducing surgical procedure ileal interposition (II) works is by increasing circulating levels of lower gut peptides that reduce food intake, such as glucagon like peptide-1 and peptide YY. However, since thi... |