α-Methyltryptophan
α-Methyltryptophan structure
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Common Name | α-Methyltryptophan | ||
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| CAS Number | 153-91-3 | Molecular Weight | 218.25 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 444.0±35.0 °C at 760 mmHg | |
| Molecular Formula | C12H14N2O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 222.3±25.9 °C | |
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α-[¹¹C]-methyl-L-tryptophan PET for tracer localization of epileptogenic brain regions: clinical studies.
Biomark. Med. 5(5) , 577-84, (2011) Of several molecular probes used in PET, only α-[(11)C]-methyl-L-tryptophan (AMT) is able to pinpoint the epileptic focus itself in the interictal state, by revealing a focus of increased AMT uptake, even when an MRI or glucose metabolism PET demonstrates nor... |
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α-methyl-L-tryptophan: mechanisms for tracer localization of epileptogenic brain regions.
Biomark. Med. 5(5) , 567-75, (2011) The purpose of this paper is to discuss the mechanisms of α-[(11)C]methyl-L-tryptophan (AMT) PET as an in vivo biomarker for detection of epileptogenic cortex. AMT was originally designed as a tracer to measure the serotonin synthesis rate. This tracer was fi... |
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Measuring effects of MDMA (ecstasy) abuse on the rate of cerebral serotonin synthesis.
J. Neurochem. 131(5) , 541-5, (2014)
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Brain serotonin synthesis in MDMA (ecstasy) polydrug users: an alpha-[(11) C]methyl-l-tryptophan study.
J. Neurochem. 131(5) , 634-44, (2014) 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) use may have long-term neurotoxic effects. In this study, positron emission tomography with the tracer alpha-[(11) C]methyl-l-tryptophan ((11) C-AMT) was used to compare human brain serotonin (5-HT) synthesis ... |
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Substrate promiscuity of the cyclic dipeptide prenyltransferases from Aspergillus fumigatus ( section sign).
J. Nat. Prod. 72 , 44-52, (2009) This study reports that a series of tryptophan derivatives with modifications on the side chain or at the indole ring were accepted by two cyclic dipeptide prenyltransferases, CdpNPT and FtmPT1, and converted to prenylated derivatives. The structures of the e... |
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Serotonin modulates worker responsiveness to trail pheromone in the ant Pheidole dentata.
J. Comp. Physiol. A. Neuroethol. Sens. Neural. Behav. Physiol. 198(3) , 219-27, (2012) As social insect workers mature, outside-nest tasks associated with foraging and defense are typically performed at higher frequencies. Foraging in ants is often a pheromonally mediated collective action performed by mature workers; age-dependent differences ... |
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Both acute and subchronic treatments with pindolol, a 5-HT(1A) and β₁ and β₂ adrenoceptor antagonist, elevate regional serotonin synthesis in the rat brain: an autoradiographic study.
Neurochem. Int. 61(8) , 1417-23, (2012) Antidepressant treatments, including those that increase serotonin (5-HT) neurotransmission, require several weeks or months until the onset of the therapeutic effect in depressed patients. The negative feedback on 5-HT transmission exhibited by the 5-HT(1A) ... |
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Quantification of tryptophan transport and metabolism in lung tumors using PET.
J. Nucl. Med. 50(3) , 356-63, (2009) Abnormal tryptophan metabolism catalyzed by indoleamine 2,3-dioxygenase may play a prominent role in tumor immunoresistance in many tumor types, including lung tumors. The goal of this study was to evaluate the in vivo kinetics of alpha-(11)C-methyl-l-tryptop... |
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Tryptophan metabolism in breast cancers: molecular imaging and immunohistochemistry studies.
Nucl. Med. Biol. 39(7) , 926-32, (2012) Tryptophan oxidation via the kynurenine pathway is an important mechanism of tumoral immunoresistance. Increased tryptophan metabolism via the serotonin pathway has been linked to malignant progression in breast cancer. In this study, we combined quantitative... |
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The lumped constant of α-methyl-l-tryptophan is not influenced by drugs acting through serotonergic system
Neurochem. Int. 58(7) , 826-32, (2011) Highlights ► Lumped constant converts brain trapping of tracer α-[ 14C]MTrp into 5-HT synthesis. ► The effects of drugs on the lumped constant (LC) stability were investigated. ► The regional values of LC in each of these three sets were normally distributed.... |