Guanosine 5′-[β-thio]diphosphate trilithium salt

Guanosine 5′-[β-thio]diphosphate trilithium salt Structure
Guanosine 5′-[β-thio]diphosphate trilithium salt structure
Common Name Guanosine 5′-[β-thio]diphosphate trilithium salt
CAS Number 97952-36-8 Molecular Weight 477.06500
Density N/A Boiling Point N/A
Molecular Formula C10H12Li3N5O10P2S Melting Point 230 °C (dec.)
MSDS USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

A potentially novel nicotinic receptor in Aplysia neuroendocrine cells.

J. Neurophysiol. 112(2) , 446-62, (2014)

Nicotinic receptors form a diverse group of ligand-gated ionotropic receptors with roles in both synaptic transmission and the control of excitability. In the bag cell neurons of Aplysia, acetylcholine activates an ionotropic receptor, which passes inward cur...

Role for protein kinase C in controlling Aplysia bag cell neuron excitability.

Neuroscience 179 , 41-55, (2011)

Targeting signalling molecules to ion channels can expedite regulation and assure the proper transition of changes to excitability. In the bag cell neurons of Aplysia, single-channel studies of excised patches have revealed that protein kinase C (PKC) gates a...

Conditional inhibition of forskolin-activated adenylate cyclase by guanosine diphosphate and its analog.

Arch. Biochem. Biophys. 251 , 148-155, (1986)

Forskolin-activated adenylate cyclases (AC) in intact membranes, solubilized with Lubrol or eluted following adsorption on a forskolin-Sepharose column, were examined for inhibition by GDP and GDP beta S. AC in intact membranes of rat or rabbit adipocytes was...

GDP beta S enhances the activation of phospholipase C caused by thrombin in human platelets: evidence for involvement of an inhibitory GTP-binding protein.

Biochem. Biophys. Res. Commun. 144 , 1188-1196, (1987)

Guanosine 5'-O-thiotriphosphate (GTP gamma S) and thrombin stimulate the activity of phospholipase C in platelets that have been permeabilized with saponin and whose inositol phospholipids have been prelabeled with [3H]inositol. Ca2+ has opposite effects on t...

Inhibition of GDP beta S of agonist-activated phospholipase C in human platelets requires cell permeabilization.

Biochem. Biophys. Res. Commun. 153 , 417-421, (1988)

The inhibition by guanosine 5'-[beta-thio]diphosphate (GDP beta S) of phospholipase C was compared in intact and saponin-permeabilized human platelets in order to assess whether effects of GDP beta S on phospholipase C activation unrelated to guanine nucleoti...

Gi-protein inhibitor, guanosine 5′-O-(2-thiodiphosphate), induces senescence-associated β-galactosidase positive cell formation through CREB phosphorylation

Leuk. Res. 86 , 683-90, (2010)

Aims We evaluated Gi-protein inhibitor, guanosine 5′-O-(2-thiodiphosphate)(GOT)-induced senescence-associated(SA)-β-galactosidase(Gal) positive cell formation to determine if it occurred through phosphorylation of cyclic AMP-dependent response element binding...