fumagillin
fumagillin structure
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Common Name | fumagillin | ||
|---|---|---|---|---|
| CAS Number | 23110-15-8 | Molecular Weight | 458.54400 | |
| Density | 1.19g/cm3 | Boiling Point | 608.8ºC at 760mmHg | |
| Molecular Formula | C26H34O7 | Melting Point | >190ºC-192ºC | |
| MSDS | Chinese USA | Flash Point | 198.8ºC | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
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Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide.
ACS Nano 8(7) , 7305-17, (2014) Antiangiogenesis has been extensively explored for the treatment of a variety of cancers and certain inflammatory processes. Fumagillin, a mycotoxin produced by Aspergillus fumigatus that binds methionine aminopeptidase 2 (MetAP-2), is a potent antiangiogenic... |
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Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats.
PLoS ONE 7(4) , e35388, (2012) Pulmonary Hypertension (PH) is a pathophysiologic condition characterized by hypoxemia and right ventricular strain. Proliferation of fibroblasts, smooth muscle cells, and endothelial cells is central to the pathology of PH in animal models and in humans. Met... |
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The Aspergillus fumigatus toxin fumagillin suppresses the immune response of Galleria mellonella larvae by inhibiting the action of haemocytes.
Microbiology 157(Pt 5) , 1481-8, (2011) Larvae of Galleria mellonella are widely used to evaluate microbial virulence and to assess the in vivo efficacy of antimicrobial agents. The aim of this work was to examine the ability of an Aspergillus fumigatus toxin, fumagillin, to suppress the immune res... |
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Methionine aminopeptidase 2 is required for HSC initiation and proliferation.
Blood 118(20) , 5448-57, (2011) In a chemical screening, we tested the antiangiogenic effects of fumagillin derivatives and identified fumagillin as an inhibitor of definitive hematopoiesis in zebrafish embryos. Fumagillin is known to target methionine aminopeptidase II (MetAP2), an enzyme ... |
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Rapid determination of fumagillin residues in honey by liquid chromatography-tandem mass spectrometry using the QuEChERS method.
J. AOAC Int. 94(3) , 878-85, (2011) A new, rapid, and efficient method for determining the fumagillin residues in honey was developed. The samples extracted were analyzed using LC/MS/MS. Chromatographic separation of fumagillin was performed in gradient mode on a C8 column (100 x 2.0 mm, 5 micr... |
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Culture condition-dependent metabolite profiling of Aspergillus fumigatus with antifungal activity.
Fungal Biol. 117(3) , 211-9, (2013) Three sections of Aspergillus (five species, 21 strains) were classified according to culture medium-dependent and time-dependent secondary metabolite profile-based chemotaxonomy. Secondary metabolites were analysed by liquid chromatography-electrospray ionis... |
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Inhibition of neutrophil function following exposure to the Aspergillus fumigatus toxin fumagillin.
J. Med. Microbiol. 59(Pt 6) , 625-33, (2010) The filamentous fungus Aspergillus fumigatus produces a variety of enzymes and toxins that may facilitate fungal colonization of tissue and evasion of the host immune response. One such toxin, fumagillin, was investigated for its ability to inhibit the action... |
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Impact of Nosema (Microsporidia) infection and fumagillin treatment on Lygus lineolaris (Hemiptera: Miridae).
J. Invertebr. Pathol. 111(2) , 101-5, (2012) A consistent supply of healthy tarnished plant bug, Lygus lineolaris (Palisot de Beauvois) (Hemiptera: Miridae), is necessary for the development of novel management strategies targeting this pest. After being in culture for several years, a substantial porti... |
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Fumagillin-induced aseptic meningoencephalitis in a kidney transplant recipient with microsporidiosis.
Transpl. Infect. Dis. 14(6) , E147-9, (2012) Microsporidiosis is an opportunistic infection in organ transplant recipients and patients with other cellular immunodeficiency. Fumagillin is an effective treatment against Enterocytozoon bieneusi, one of the two main species causing the microsporidiosis inv... |
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Specificity in the interaction of natural products with their target proteins--a biochemical and structural insight.
Mini Rev. Med. Chem. 10(6) , 540-9, (2010) Natural products are an abundant source of anti cancer agents. They act as cytotoxic drugs, and inhibitors of apoptosis, transcription, cell proliferation and angiogenesis. While pathways targeted by natural products have been well studied, there is paucity o... |