1,2-Distearoyl-sn-glycero-3-phosphocholine
1,2-Distearoyl-sn-glycero-3-phosphocholine structure
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Common Name | 1,2-Distearoyl-sn-glycero-3-phosphocholine | ||
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| CAS Number | 816-94-4 | Molecular Weight | 790.145 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C44H88NO8P | Melting Point | 236 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Immunoliposomes containing Soluble Leishmania Antigens (SLA) as a novel antigen delivery system in murine model of leishmaniasis.
Exp. Parasitol. 146 , 78-86, (2014) Development of new generation of vaccines against leishmaniasis requires adjuvants to elicit the type and intensity of immune response needed for protection. The coupling of target-specific antibodies to the liposomal surface to create immunoliposomes has app... |
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Defective functionality of HDL particles in familial apoA-I deficiency: relevance of alterations in HDL lipidome and proteome.
J. Lipid Res. 55(12) , 2509-20, (2014) To evaluate functional and compositional properties of HDL in subjects from a kindred of genetic apoA-I deficiency, two homozygotes and six heterozygotes, with a nonsense mutation at APOA1 codon -2, Q[-2]X, were recruited together with age- and sex-matched he... |
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Ultrasound triggered drug delivery with liposomal nested microbubbles.
Ultrasonics 63 , 31-8, (2015) When ultrasound contrast agent microbubbles are nested within a liposome, damage to the liposome membrane caused by both stable and inertial cavitation of the microbubble allows for release of the aqueous core of the liposome. Triggered release was not accomp... |
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Correlating liposomal adjuvant characteristics to in-vivo cell-mediated immunity using a novel Mycobacterium tuberculosis fusion protein: a multivariate analysis study.
J. Pharm. Pharmacol. 67(3) , 450-63, (2015) In this study, we have used a chemometrics-based method to correlate key liposomal adjuvant attributes with in-vivo immune responses based on multivariate analysis.The liposomal adjuvant composed of the cationic lipid dimethyldioctadecylammonium bromide (DDA)... |
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Distribution and Inhibition of Liposomes on Staphylococcus aureus and Pseudomonas aeruginosa Biofilm.
PLoS ONE 10 , e0131806, (2015) Staphylococcus aureus and Pseudomonas aeruginosa are major pathogens in chronic rhinosinusitis (CRS) and their biofilms have been associated with poorer postsurgical outcomes. This study investigated the distribution and anti-biofilm effect of cationic (+) an... |
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Decreasing Transmembrane Segment Length Greatly Decreases Perfringolysin O Pore Size.
J. Membr. Biol. 248 , 517-27, (2015) Perfringolysin O (PFO) is a transmembrane (TM) β-barrel protein that inserts into mammalian cell membranes. Once inserted into membranes, PFO assembles into pore-forming oligomers containing 30-50 PFO monomers. These form a pore of up to 300 Å, far exceeding ... |
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Epidermal growth factor receptor-targeted immunoliposomes for delivery of celecoxib to cancer cells.
Int. J. Pharm. 479(2) , 364-73, (2015) Cyclooxygenase-2 (COX-2) is highly expressed in many different cancers. Therefore, the inhibition of the COX-2 pathway by a selective COX-2 inhibitor, celecoxib (CLX), may be an alternative strategy for cancer prevention and therapy. Liposomal drug delivery s... |
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Synthesis and evaluation of glyco-coated liposomes as drug carriers for active targeting in drug delivery systems.
Carbohydr. Res. 405 , 78-86, (2015) Novel sugar-conjugated cholesterols, β-Gal-, α-Man-, β-Man-, α-Fuc-, and β-Man-6P-S-β-Ala-Chol, were synthesized and incorporated into liposomes. In vitro experiments using the glyco-coated liposomes showed that the glyco-coated liposomes are efficiently take... |
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In Vivo Transfection and Detection of Gene Expression of Stem Cells Preloaded with DNA-carrying Microbubbles.
Radiology 276 , 518-25, (2015) To determine whether (a) stem cells loaded with DNA-carrying microbubbles (MBs) can be transfected in vivo, (b) the cells remain alive to express the gene, and (c) gene expression is sufficiently robust to be detected in vivo.The study was approved by the Ins... |
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Porphyrin-phospholipid liposomes with tunable leakiness.
J. Control. Release 220 , 484-94, (2015) Drug bioavailability is a key consideration for drug delivery systems. When loaded with doxorubicin, liposomes containing 5 molar % porphyrin-phospholipid (HPPH liposomes) exhibited in vitro and in vivo serum stability that could be fine-tuned by varying the ... |