816-94-4

816-94-4 structure

Name: 1,2-Distearoyl-sn-glycero-3-phosphocholine
Chemical Name: 1,2-distearoyl-sn-glycero-3-phosphocholine
CAS Number: 816-94-4
Molecular Formula: C₄₄H₈₈NO₈P
Molecular Weight: 790.145
Catalog: Research Areas Others
Create Date: 2018-12-27 17:07:32
Modify Date: 2024-01-02 15:25:56
1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2].

Name	1,2-distearoyl-sn-glycero-3-phosphocholine
Synonyms	EINECS 212-440-2 MFCD00036905 (2R)-2,3-Bis(stearoyloxy)propyl 2-(trimethylammonio)ethyl phosphate 1,2-Distearoyl-sn-glycero-3-phosphocholine Ethanaminium, 2-[[[(2R)-2,3-bis[(1-oxooctadecyl)oxy]propoxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt (2R)-2,3-bis(octadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate L-α-PHOSPHATIDYLCHOLINE, DISTEAROYL

Description	1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	In empty lipid nanoparticle (LNP) systems that do not contain siRNA, DSPC-cholesterol resides in outer layers, whereas in loaded systems a portion of the DSPC-cholesterol is internalised together with siRNA[2].
References	[1]. Andrew D Miller. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811. [2]. Jayesh A Kulkarni, et al. On the role of helper lipids in lipid nanoparticle formulations of siRNA. Nanoscale. 2019 Nov 21;11(45):21733-21739.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport