1,2-Distearoyl-sn-glycero-3-phosphocholine

Modify Date: 2025-08-20 18:52:35

1,2-Distearoyl-sn-glycero-3-phosphocholine Structure
1,2-Distearoyl-sn-glycero-3-phosphocholine structure
 Common Name 1,2-Distearoyl-sn-glycero-3-phosphocholine
CAS Number 816-94-4 Molecular Weight 790.145
Density N/A Boiling Point N/A
Molecular Formula C44H88NO8P Melting Point 236 °C
MSDS Chinese USA Flash Point N/A

 Use of 1,2-Distearoyl-sn-glycero-3-phosphocholine


1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2].

 Names

Name 1,2-distearoyl-sn-glycero-3-phosphocholine
Synonym More Synonyms

  Biological Activity

Description 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2].
Related Catalog
In Vitro In empty lipid nanoparticle (LNP) systems that do not contain siRNA, DSPC-cholesterol resides in outer layers, whereas in loaded systems a portion of the DSPC-cholesterol is internalised together with siRNA[2].
References

[1]. Andrew D Miller. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811.

[2]. Jayesh A Kulkarni, et al. On the role of helper lipids in lipid nanoparticle formulations of siRNA. Nanoscale. 2019 Nov 21;11(45):21733-21739.

 Chemical & Physical Properties

Melting Point 236 °C
Molecular Formula C44H88NO8P
Molecular Weight 790.145
Exact Mass 789.624756
PSA 121.00000
LogP 13.00

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport

 Synthetic Route

 Articles54

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 Synonyms

EINECS 212-440-2
MFCD00036905
(2R)-2,3-Bis(stearoyloxy)propyl 2-(trimethylammonio)ethyl phosphate
1,2-Distearoyl-sn-glycero-3-phosphocholine
Ethanaminium, 2-[[[(2R)-2,3-bis[(1-oxooctadecyl)oxy]propoxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt
(2R)-2,3-bis(octadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate
L-α-PHOSPHATIDYLCHOLINE, DISTEAROYL
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Chemsrc provides CAS#:816-94-4 MSDS, density, melting point, boiling point, structure, etc. Its name is 1,2-Distearoyl-sn-glycero-3-phosphocholine>> amp version: 1,2-Distearoyl-sn-glycero-3-phosphocholine

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