4-Brombut-1-en

4-Brombut-1-en Structure
4-Brombut-1-en structure
Common Name 4-Brombut-1-en
CAS Number 5162-44-7 Molecular Weight 135.002
Density 1.3±0.1 g/cm3 Boiling Point 99.3±9.0 °C at 760 mmHg
Molecular Formula C4H7Br Melting Point N/A
MSDS Chinese USA Flash Point 9.4±0.0 °C
Symbol GHS02 GHS07 GHS08
GHS02, GHS07, GHS08
Signal Word Danger

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Total synthesis and molecular target of largazole, a histone deacetylase inhibitor.

J. Am. Chem. Soc. 130(26) , 8455-9, (2008)

Full details of the concise and convergent synthesis (eight steps, 19% overall yield), its extension to the preparation of a series of key analogues, and the molecular target and pharmacophore of largazole are described. Central to the synthesis of largazole ...