2-chloroacetonitrile
2-chloroacetonitrile structure
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Common Name | 2-chloroacetonitrile | ||
|---|---|---|---|---|
| CAS Number | 107-14-2 | Molecular Weight | 75.497 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 126.5±0.0 °C at 760 mmHg | |
| Molecular Formula | C2H2ClN | Melting Point | 38℃ | |
| MSDS | Chinese USA | Flash Point | 47.8±0.0 °C | |
| Symbol |
GHS02, GHS06, GHS09 |
Signal Word | Danger | |
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Genotoxic activity of five haloacetonitriles: comparative investigations in the single cell gel electrophoresis (comet) assay and the ames-fluctuation test.
Environ. Mol. Mutagen. 36(1) , 52-8, (2000) Halogenated acetonitriles (HANs) are known to be water disinfectant by-products. Their mutagenicity and carcinogenicity have been shown in different test systems in vivo and in vitro. They also have clastogenic properties. In this study, the ability of HAN to... |
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Percutaneous absorption of haloacetonitriles and chloral hydrate and simulated human exposures.
J. Appl. Toxicol. 32(6) , 387-94, (2012) Disinfection-by-products (DBPs) have long been a human health concern and many are known carcinogens and teratogens. Skin is exposed to DBPs in water through bathing and swimming; however, dermal uptake of many DBPs has not been characterized. The present stu... |
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Chloroacetonitrile induces intrauterine growth restriction and musculoskeletal toxicity in fetal mouse.
Toxicol. Ind. Health 24(8) , 511-8, (2008) Chloroacetonitrile (CAN) is a by-product of chlorination of drinking water. Epidemiological studies indicate that it might present a hazard to human health. The present study was designed to investigate the potential adverse effects of intrauterine exposure t... |
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Haloacetonitriles are low K1 inhibitors of bacterial dichloromethane dehalogenases.
Biochem. Biophys. Res. Commun. 197(2) , 853-8, (1993) Distinct dichloromethane dehalogenases from Methylobacterium sp. strain DM4 and Methylophilus DM11 were inhibited by low concentrations of haloacetonitriles. Chloroacetonitrile (ClCH2CN) showed maximal inhibition at a stoichiometry of 1 mol inhibitor:1 mol ho... |
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Mechanisms of hepatotoxicity of chloroacetonitrile - an end product of water chlorination.
Pak. J. Pharm. Sci. 26(1) , 145-52, (2013) Chloroacetonitrile is a disinfectant by-product of chlorination of drinking water and is considered as a direct-acting mutagenic and carcinogenic agent. Time-course and dose-response studies were performed to examine the mechanism of chloroacetonitrile-induce... |
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Chloroacetonitrile induces oxidative stress and apoptosis in mouse fetal liver.
Toxicol. Lett. 190(2) , 123-7, (2009) Chloroacetonitrile (CAN) is a disinfection by-product of chlorination of drinking water. The present study was designed to investigate the potential adverse effects of maternal exposure to CAN on fetal liver in mice. Based on an initial dose-response experime... |
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Chloroacetonitrile.
IARC Monogr. Eval. Carcinog. Risks Hum. 71 Pt 3 , 1325-9, (1999)
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Role of protonation and of axial ligands in the reductive dechlorination of alkyl chlorides by vitamin B12 complexes. Reductive cleavage of chloroacetonitrile by Co(I) cobalamins and cobinamides.
J. Am. Chem. Soc. 127(14) , 5049-55, (2005) Cobalt(I) cobalamin and cobinamide are efficient catalysts of the hydrogenolysis of aliphatic chloro compounds. Taking chloroacetonitrile as example, the first requirement for high catalytic efficiency is fulfilled by the high reactivity of the Co(I) complex ... |
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The hydration of chloroacetonitriles catalyzed by mono- and dinuclear Ru(II)- and Os(II)-arene complexes.
Chem. Biodivers. 5(10) , 2060-6, (2008) The hydration of nitriles to the corresponding amides is an important reaction for both laboratory and industry purposes. The classical synthesis method requires harsh conditions, gives low yields, and is nonselective due to further hydrolysis of the amides i... |
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Studies on the mechanism of haloacetonitriles toxicity: quantitative whole body autoradiographic distribution of [2-14C]chloroacetonitrile in rats.
Toxicology 67(3) , 279-302, (1991) Chloroacetonitrile (CAN), a drinking water disinfectant by-product, possesses mutagenic and carcinogenic properties. The objective of this study was to investigate the biologic fate of CAN, using whole body autoradiographic (WBA) techniques. Male Sprague-Dawl... |