2-Chloroacetamide
2-Chloroacetamide structure
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Common Name | 2-Chloroacetamide | ||
|---|---|---|---|---|
| CAS Number | 79-07-2 | Molecular Weight | 93.512 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 256.0±13.0 °C at 760 mmHg | |
| Molecular Formula | C2H4ClNO | Melting Point | 116-118 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 108.6±19.8 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells.
Oncotarget 6(8) , 6014-28, (2015) Alpha fetoprotein (AFP) is a clinical biomarker of hepatocellular carcinoma (HCC). Here, we found that miR-1236 is down-regulated, whereas AFP is highly expressed in HCC tissues and cells. We demonstrated that miR-1236 directly targets the 3'UTR of AFP and do... |
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Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.
EMBO Rep. 16 , 939-54, (2015) Mutations in the mitochondrial protein kinase PINK1 are associated with autosomal recessive Parkinson disease (PD). We and other groups have reported that PINK1 activates Parkin E3 ligase activity both directly via phosphorylation of Parkin serine 65 (Ser(65)... |
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Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging.
Proc. Natl. Acad. Sci. U. S. A. 111(37) , E3880-9, (2014) Many metabolic pathways are critically regulated during development and aging but little is known about the molecular mechanisms underlying this regulation. One key metabolic cascade in eukaryotes is the mevalonate pathway. It catalyzes the synthesis of stero... |
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Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling.
Nat. Commun. 5 , 5409, (2014) Small ubiquitin-related modifiers (SUMO) are evolutionarily conserved ubiquitin-like proteins that regulate several cellular processes including cell cycle progression, intracellular trafficking, protein degradation and apoptosis. Despite the importance of pr... |
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Protein quality control at the inner nuclear membrane.
Nature 516(7531) , 410-3, (2014) The nuclear envelope is a double membrane that separates the nucleus from the cytoplasm. The inner nuclear membrane (INM) functions in essential nuclear processes including chromatin organization and regulation of gene expression. The outer nuclear membrane i... |
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Processing of protein ADP-ribosylation by Nudix hydrolases.
Biochem. J. 468 , 293-301, (2015) ADP-ribosylation is a post-translational modification (PTM) of proteins found in organisms from all kingdoms of life which regulates many important biological functions including DNA repair, chromatin structure, unfolded protein response and apoptosis. Severa... |
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Phosphoproteomic approach to characterize protein mono- and poly(ADP-ribosyl)ation sites from cells.
J. Proteome Res. 13(8) , 3510-22, (2014) Poly(ADP-ribose), or PAR, is a cellular polymer implicated in DNA/RNA metabolism, cell death, and cellular stress response via its role as a post-translational modification, signaling molecule, and scaffolding element. PAR is synthesized by a family of protei... |
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Palladium-catalyzed α-arylation of 2-chloroacetates and 2-chloroacetamides.
J. Org. Chem. 78(8) , 4123-31, (2013) A method has been developed for the Pd-catalyzed synthesis of α-(hetero)aryl esters and amides through a Suzuki-Miyaura cross-coupling reaction. This method avoids the use of strong base, does not necessitate inert or low temperature formation of reagents, an... |
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N-Myristoylation of the Rpt2 subunit of the yeast 26S proteasome is implicated in the subcellular compartment-specific protein quality control system.
J. Proteomics 130 , 33-41, (2015) Ubiquitination is the posttranslational modification of a protein by covalent attachment of ubiquitin. Controlled proteolysis via the ubiquitin-proteasome system (\UPS) alleviates cellular stress by clearing misfolded proteins. In budding yeast, UPS within th... |
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Effect of safeners on damage of human erythrocytes treated with chloroacetamide herbicides.
Environ. Toxicol. Pharmacol. 36(2) , 368-77, (2013) Chloroacetamides are used as pre-emergent substances for growth control of annual grasses and weeds. Since they can be harmful for crop plants, protective compounds (safeners) are used along with herbicides. So far, their effects on human blood cells have not... |