Isopentyl nitrite
Isopentyl nitrite structure
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Common Name | Isopentyl nitrite | ||
|---|---|---|---|---|
| CAS Number | 110-46-3 | Molecular Weight | 117.146 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 99.1±9.0 °C at 760 mmHg | |
| Molecular Formula | C5H11NO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 10.0±0.0 °C | |
| Symbol |
GHS02, GHS06 |
Signal Word | Danger | |
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Poly-S-nitrosated human albumin enhances the antitumor and antimetastasis effect of bevacizumab, partly by inhibiting autophagy through the generation of nitric oxide.
Cancer Sci. 106(2) , 194-200, (2015) Autophagy is one of the major causes of drug resistance. For example, the angiogenesis inhibitor bevacizumab shows only transient and short-term therapeutic effects, whereas long-term therapeutic benefits are rarely observed, probably due to hypoxia-induced a... |
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Tuning of poly-S-nitrosated human serum albumin as superior antitumor nanomedicine.
J. Pharm. Sci. 103(7) , 2184-8, (2014) Macromolecules have been developed as carriers of low-molecular-weight drugs in drug delivery systems (DDS) to improve their pharmacokinetic profile or to promote their uptake in tumor tissue via enhanced permeability and retention (EPR) effects. We have prev... |
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Molecular mechanisms of nitrovasodilator bioactivation.
Basic Res. Cardiol. 86 , 37-50, (1991) All nitrovasodilators act intracellularly by a common molecular mechanism. This is characterized by the release of nitric oxide (NO). They are, thus, prodrugs or carriers of the active principle NO, responsible for endothelial controlled vasodilation. The rat... |
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Electron paramagnetic resonance and spin trapping study of radicals formed during reaction of aromatic amines with isoamyl nitrite under aprotic conditions.
Free Radic. Res. Commun. 10(1-2) , 47-56, (1990) Diazotization of primary aromatic amines with isoamyl nitrite in benzene at room temperature was studied employing EPR and spin trapping techniques. Nitrosodurene (ND), 2-methyl-2-nitrosopropane (MNP), and 5,5-dimethyl-pyrroline N-oxide (DMPO) were used as sp... |
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Pentobarbital-like discriminative stimulus properties of halothane, 1,1,1-trichloroethane, isoamyl nitrite, flurothyl and oxazepam in mice.
J. Pharmacol. Exp. Ther. 241(2) , 507-15, (1987) Volatile inhalants represent a diverse group of chemicals which pose a public health problem because of their abuse potential and neurobehavioral toxicity. Although relatively little is known about their pharmacology, they share certain pharmacological proper... |
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Synthesis of peroxynitrite in a two-phase system using isoamyl nitrite and hydrogen peroxide.
Anal. Biochem. 236(2) , 242-9, (1996) A new method for the preparation of high concentrations of peroxynitrite (up to 1 M) is described. The synthesis uses a two-phase system and involves a displacement reaction by the hydroperoxide anion (in the aqueous phase) on isoamyl nitrite (in the organic ... |
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Vascular and hemodynamic differences between organic nitrates and nitrites.
J. Pharmacol. Exp. Ther. 280(1) , 326-31, (1997) Because nitroglycerin (NTG, an organic nitrate) and isoamyl nitrite have similar chemical structures and a common mechanism of vascular relaxation (i.e., conversion to nitric oxide in vascular tissues and activation of guanylyl cyclase), it has often been ass... |
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The cycloaddition reaction of I(h)-Sc₃N@C₈₀ with 2-amino-4,5-diisopropoxybenzoic acid and isoamyl nitrite to produce an open-cage metallofullerene.
Angew. Chem. Int. Ed. Engl. 50(20) , 4658-62, (2011)
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Acute effects of some volatile nitrites on motor performance and lethality in mice.
Neurobehav. Toxicol. Teratol. 8(2) , 139-42, (1986) Mice were examined for effects on lethality and motor performance on an inverted screen test following inhalation exposure to isoamyl, n-butyl and isobutyl nitrite. All three nitrites produced concentration-related effects on both measures, with EC50s for mot... |
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Synthesis of peroxynitrite using isoamyl nitrite and hydrogen peroxide in a homogeneous solvent system.
Anal. Biochem. 354(2) , 165-8, (2006) A method for the synthesis of peroxynitrite is described. It involves nitrosation of H2O2 at pH> or = 12.5 by isoamyl or butyl nitrite in mixed solvents of isopropyl alcohol (IPA) and water at 25+/-1 degrees C. Maximum yields of peroxynitrite are obtained aft... |