Fluvastatin Sodium
Fluvastatin Sodium structure
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Common Name | Fluvastatin Sodium | ||
|---|---|---|---|---|
| CAS Number | 93957-55-2 | Molecular Weight | 434.46 | |
| Density | N/A | Boiling Point | 681.8ºC at 760 mmHg | |
| Molecular Formula | C24H26FNNaO4+ | Melting Point | 194-197ºC | |
| MSDS | USA | Flash Point | N/A | |
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Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug-drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys.
Drug Metab. Pharmacokinet. 30(2) , 198-204, (2015) Since drug-drug interaction (DDI) can affect organic anion-transporting polypeptide (OATP) and cause clinical events, prediction of such DDI is important in early clinical development. Although statins are useful probes for OATP-mediated DDI, endogenous probe... |
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3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice.
APMIS 121(5) , 422-30, (2013) Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, have been shown to ameliorate a number of vascular diseases. We evaluated the inflammatory and angiogenic components of the fibrovascular tissue induced by subcutaneous implants in... |
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The effects of different types of statins on proliferation and migration of HGF-induced Human Umbilical Vein Endothelial Cells (HUVECs).
Eur. Rev. Med. Pharmacol. Sci. 17(21) , 2874-83, (2013) Statins are HMG-CoA reductase inhibitors within the framework of cholesterol biosynthesis and used to lower the low-density lipoprotein (LDL). There are other aspects of statins can deploy a protective effect, even without the LDL's lowering. The aim of this ... |
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Antithrombotic actions of statins involve PECAM-1 signaling.
Blood 122(18) , 3188-96, (2013) Statins are widely prescribed cholesterol-lowering drugs that are a first-line treatment of coronary artery disease and atherosclerosis, reducing the incidence of thrombotic events such as myocardial infarction and stroke. Statins have been shown to reduce pl... |
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Simvastatin inhibits the core promoter of the TXNRD1 gene and lowers cellular TrxR activity in HepG2 cells.
Biochem. Biophys. Res. Commun. 430(1) , 90-4, (2013) Thioredoxin reductase 1 (TrxR1) is a selenocysteine-containing redox-active enzyme that is thought to be important during carcinogenesis. We have recently shown that treatment with statins, HMGCoA reductase inhibitors, reduces the levels of TrxR1 in liver of ... |
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Effects of combined prednisone + fluvastatin on cholesterol and bilirubin in pediatric patients with minimal change nephropathy.
Clin. Ther. 35(3) , 286-93, (2013) Nephrotic syndrome is associated with hyperlipidemia and low serum bilirubin. Corticosteroids and statins are routinely administered to patients with this syndrome. However, knowledge of the mechanisms that underlie hyperlipidemia is incomplete.The aim of thi... |
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Effect of liandouqingmai recipe on quality of life and inflammatory reactions of patients with coronary heart disease.
J. Tradit. Chin. Med. 34(5) , 539-43, (2014) To observe the effect of Liandouqingmai recipe (Chinese herbal medicine compound preparation) on the quality of life (QOL) and inflammatory reaction of patients with coronary heart disease (CHD).A total of 101 CHD patients were randomized into two groups: tre... |
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Symmetric dimethylarginine as predictor of graft loss and all-cause mortality in renal transplant recipients.
Transplantation 98(11) , 1219-25, (2014) Elevated symmetric dimethylarginine (SDMA) has been shown to predict cardiovascular events and all cause mortality in diverse populations. The potential role of SDMA as a risk marker in renal transplant recipients (RTR) has not been investigated.We analyzed S... |
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Involvement of peptidyl-prolyl isomerase Pin1 in the inhibitory effect of fluvastatin on endothelin-1-induced cardiomyocyte hypertrophy
Life Sci. 102(2) , 98-104, (2014) Aims Cardiac hypertrophy is elicited by endothelin (ET)-1 as well as other neurohumoral factors, hemodynamic overload, and oxidative stress; HMG-CoA reductase inhibitors (statins) were shown to inhibit cardiac hypertrophy partly via the anti-oxidative stress.... |
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Fluvastatin attenuates hepatic steatosis-induced fibrogenesis in rats through inhibiting paracrine effect of hepatocyte on hepatic stellate cells.
BMC Gastroenterol. 15 , 22, (2015) Non-alcoholic steatohepatitis (NASH) is associated with hepatic fibrogenesis. Despite well-known cholesterol-lowering action of statins, their mechanisms against NASH-mediated fibrogenesis remain unclear. This study aimed at investigating the in vitro and in ... |