Amlodipine besylate
Amlodipine besylate structure
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Common Name | Amlodipine besylate | ||
|---|---|---|---|---|
| CAS Number | 111470-99-6 | Molecular Weight | 567.051 | |
| Density | 1.227g/cm3 | Boiling Point | 527.2ºC at 760 mmHg | |
| Molecular Formula | C26H31ClN2O8S | Melting Point | 199-201°C | |
| MSDS | Chinese USA | Flash Point | 272.6ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling.
Br. J. Pharmacol. 171(22) , 5076-92, (2014) Previously, a systems pharmacology model was developed characterizing drug effects on the interrelationship between mean arterial pressure (MAP), cardiac output (CO) and total peripheral resistance (TPR). The present investigation aims to (i) extend the previ... |
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[Hypertension. Goal: achieving target blood pressure with only 1 pill daily].
MMW Fortschr. Med. 155(6) , 66-7, (2013)
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Comparative study between derivative spectrophotometry and multivariate calibration as analytical tools applied for the simultaneous quantitation of Amlodipine, Valsartan and Hydrochlorothiazide.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 113 , 215-23, (2013) Four simple, accurate and specific methods were developed and validated for the simultaneous estimation of Amlodipine (AML), Valsartan (VAL) and Hydrochlorothiazide (HCT) in commercial tablets. The derivative spectrophotometric methods include Derivative Rati... |
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Comparison of benazepril plus amlodipine or hydrochlorothiazide in high-risk patients with hypertension and coronary artery disease.
Am. J. Cardiol. 112(2) , 255-9, (2013) Combination therapy with benazepril 40 mg and amlodipine 10 mg (B+A) has been shown to be more effective than benazepril 40 mg and hydrochlorothiazide (HCTZ) 25 mg (B+H) in reducing cardiovascular (CV) events in high-risk patients with stage 2 hypertension wi... |
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[Telangiectasia during amlodipine therapy].
Ann. Dermatol. Venereol. 140(3) , 202-5, (2013) Calcium inhibitors are recommended as first-line treatment in hypertension. We report the development of telangiectasia on the trunk and upper limbs in a female patient on amlodipine (Amlor(®)) that subsided on treatment discontinuation.A 63-year-old woman co... |
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A comparative pharmacokinetic study of a fixed dose combination for essential hypertensive patients: a randomized crossover study in healthy human volunteers.
Drug Res. (Stuttg.) 63(4) , 177-84, (2013) This study was aimed to investigate the relative bioavailability of fixed-dose-combination (FDC) product of amlodipine, telmisartan and hydrochlorothiazide with individual marketed products in healthy male volunteers. Control of blood pressure with fixed dose... |
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Olmesartan-based therapies: an effective way to improve blood pressure control and cardiovascular protection.
J. Hypertens. 31 Suppl 1 , S13-7, (2013) The main purpose in hypertension treatment is the reduction of cardiovascular disease burden. Among different first-line antihypertensive drug classes, angiotensin-receptor blockers are characterized by their both good effectiveness and tolerability. Furtherm... |
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Efficacy of amlodipine/olmesartan medoxomil ± hydrochlorothiazide in patients aged ≥ 65 or < 65 years with uncontrolled hypertension on prior monotherapy.
Postgrad. Med. 125(2) , 124-34, (2013) Our subanalysis evaluated the efficacy of an amlodipine/olmesartan medoxomil (AML/OM)-based titration regimen to achieve blood pressure (BP) goals among patients aged ≥ 65 years. In this dose-titration study, 999 patients (228 of whom were aged ≥ 65 years) wi... |
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Association of marketing interactions with medical trainees' knowledge about evidence-based prescribing: results from a national survey.
JAMA Intern. Med. 174(8) , 1283-90, (2014) In recent years, numerous US medical schools and academic medical centers have enacted policies preventing pharmaceutical sales representatives from interacting directly with students. Little is known about how pharmaceutical sales representatives affect trai... |
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Liquisolid technique: a promising alternative to conventional coating for improvement of drug photostability in solid dosage forms.
Expert Opin. Drug Deliv. 10(10) , 1335-43, (2013) The objective of this study was to investigate the photoprotective effect of liquisolid technique on amlodipine, a calcium channel blocker antihypertensive drug, representing a photosensitive drug model.Several liquisolid formulations were prepared using prop... |