carazolol
carazolol structure
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Common Name | carazolol | ||
|---|---|---|---|---|
| CAS Number | 57775-29-8 | Molecular Weight | 298.38 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 531.2±40.0 °C at 760 mmHg | |
| Molecular Formula | C18H22N2O2 | Melting Point | 133-137 °C | |
| MSDS | Chinese USA | Flash Point | 275.1±27.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Determination of 15 sedative residues in mutton by rapid resolution liquid chromatography-tandem mass spectrometry.
J. Sci. Food Agric. 95(3) , 598-606, (2015) The use of xenobiotic compounds in animal husbandry has given rise to consumer anxieties regarding residual risk and food safety. Thus, animal tissues have become main samples for residue analysis and food safety for sedatives. In this study, a rapid resoluti... |
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Lipophilicity of basic drugs measured by hydrophilic interaction chromatography.
J. Med. Chem. 52 , 3416-9, (2009) RPLC gains acceptance in pharmaceutical research for the rapid determination of lipophilicity but remains limited for the determination of partition coefficients of moderate to strong basic compounds under their neutral form because stationary phases are not ... |
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Constitutive phospholipid scramblase activity of a G protein-coupled receptor.
Nat. Commun. 5 , 5115, (2014) Opsin, the rhodopsin apoprotein, was recently shown to be an ATP-independent flippase (or scramblase) that equilibrates phospholipids across photoreceptor disc membranes in mammalian retina, a process required for disc homoeostasis. Here we show that scrambli... |
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[Determination of azaperone and carazolol residues in animals kidney using LC-MS/MS method].
Rocz. Panstw. Zakl. Hig. 60(1) , 19-23, (2009) The method is presented to analyze azaperone and carazolol in pigs kidney. Samples were extracted with acetonitryle. The determination was performed by LC-ESI-MS/MS. The LC was equipped with column Luna C18 Phenomenex. Haloperidol was used as internal standar... |
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Structure and function of an irreversible agonist-β(2) adrenoceptor complex.
Nature 469(7329) , 236-40, (2011) G-protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins that modulate biological function by initiating cellular signalling in response to chemically diverse agonists. Despite recent progress in the structural biology of GPCRs, the molec... |
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High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists.
J. Med. Chem. 51 , 396-9, (2008) Accurate determinations of lipophilicity indices benefit from recent advances in chromatographic sciences such as the launch of ultraperformance liquid chromatography (UPLC). The fast strategy presented here emerges as a powerful method suitable for high-thro... |
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Structural biology: a receptor unlocked.
Nature 450(7168) , 355-6, (2007)
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Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX.
Structure 19(10) , 1424-32, (2011) Mechanism of G protein-coupled receptor (GPCR) activation and their modulation by functionally distinct ligands remains elusive. Using the technique of amide hydrogen/deuterium exchange coupled with mass spectrometry, we examined the ligand-induced changes in... |
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X-ray structure breakthroughs in the GPCR transmembrane region.
Biochem. Pharmacol. 78(1) , 11-20, (2009) G-protein-coupled receptor (GPCR) proteins [Lundstrom KH, Chiu ML, editors. G protein-coupled receptors in drug discovery. CRC Press; 2006] are the single largest drug target, representing 25-50% of marketed drugs [Overington JP, Al-Lazikani B, Hopkins AL. Ho... |
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Identifying conformational changes of the beta(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators.
J. Comput. Aided Mol. Des. 23(5) , 273-88, (2009) The new beta(2) Adrenoceptor (beta(2)AR) crystal structures provide a high-resolution snapshot of receptor interactions with two particular partial inverse agonists, (-)-carazolol and timolol. However, both experimental and computational studies of GPCR struc... |