Bis(4-nitrophenyl) phosphate
Bis(4-nitrophenyl) phosphate structure
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Common Name | Bis(4-nitrophenyl) phosphate | ||
|---|---|---|---|---|
| CAS Number | 645-15-8 | Molecular Weight | 340.182 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 545.7±60.0 °C at 760 mmHg | |
| Molecular Formula | C12H9N2O8P | Melting Point | 172-175 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 283.8±32.9 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Characterization of Species Differences in Tissue Diltiazem Deacetylation Identifies Ces2a as a Rat-Specific Diltiazem Deacetylase.
Drug Metab. Dispos. 43 , 1218-25, (2015) Diltiazem, a calcium channel blocker, is mainly metabolized via demethylation or deacetylation in humans. Diltiazem demethylation is catalyzed by cytochrome P450 2D6 and 3A4. Although it was previously reported that the area under the curve ratio of deacetyld... |
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Screening of stabilizers for LC-MS/MS analysis of clevidipine and its primary metabolite in dog whole blood.
Bioanalysis 7 , 1457-69, (2015) Clevidipine is an ester-containing antihypertensive agent that undergoes rapid hydrolysis in blood. A reliable stabilizer cocktail containing citric acid and ascorbic acid was established and the LC-MS/MS method was validated for simultaneous determination of... |
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Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation.
J. Pharmacol. Exp. Ther. 344(3) , 665-72, (2013) Clopidogrel pharmacotherapy is associated with substantial interindividual variability in clinical response, which can translate into an increased risk of adverse outcomes. Clopidogrel, a recognized substrate of hepatic carboxylesterase 1 (CES1), undergoes ex... |
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A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834.
Drug Metab. Dispos. 43 , 908-15, (2015) GDC-0834, a Bruton's tyrosine kinase inhibitor investigated as a potential treatment of rheumatoid arthritis, was previously reported to be extensively metabolized by amide hydrolysis such that no measurable levels of this compound were detected in human circ... |
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Site-directed mutagenesis maps interactions that enhance cognate and limit promiscuous catalysis by an alkaline phosphatase superfamily phosphodiesterase.
Biochemistry 52(51) , 9167-76, (2013) Catalytic promiscuity, an evolutionary concept, also provides a powerful tool for gaining mechanistic insights into enzymatic reactions. Members of the alkaline phosphatase (AP) superfamily are highly amenable to such investigation, with several members havin... |
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Synthesis of triazole Schiff bases: novel inhibitors of nucleotide pyrophosphatase/phosphodiesterase-1.
Bioorg. Med. Chem. 22(22) , 6509-14, (2015) A series of Schiff base triazoles 1–25 was synthesized and evaluated for their nucleotide pyrophosphatase/phosphodiesterase-1 inhibitory activities. Among twenty-five compounds, three compounds 10 (IC50 = 132.20 ± 2.89 lM), 13 (IC50 = 152.83 ± 2.39 lM), and 2... |
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Hydrolysis of bis(p-nitrophenyl)phosphate by tetravalent metal complexes with Klaui's oxygen tripodal ligand.
Inorg. Chem. 49(5) , 2232-8, (2010) The treatment of HfCl(4) with NaL(OEt) (L(OEt)(-) = [(eta(5)-C(5)H(5))Co{P(O)(OEt)(2)}(3)](-)) in nitric acid afforded L(OEt)Hf(NO(3))(3) (1). Hydrolysis of 1 in acetone/water (4:1, v/v) yielded the hydroxy-bridged dimer [(L(OEt))(2)Hf(2)(H(2)O)(4)(mu-OH)(2)]... |
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Mechanistic role of each metal ion in Streptomyces dinuclear aminopeptidase: PEPTIDE hydrolysis and 7x10(10)-fold rate enhancement of phosphodiester hydrolysis.
J. Inorg. Biochem. 104(1) , 19-29, (2010) The dinuclear aminopeptidase from Streptomyces griseus (SgAP) and its metal derivatives catalyze the hydrolysis of the phosphoester bis(p-nitrophenyl) phosphate (BNPP) and the phosphonate ester p-nitrophenyl phenylphosphonate with extraordinary rate enhanceme... |
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Crystal structure of an EAL domain in complex with reaction product 5'-pGpG.
PLoS ONE 7(12) , e52424, (2012) FimX is a large multidomain protein containing an EAL domain and involved in twitching motility in Pseudomonas aeruginosa. We present here two crystallographic structures of the EAL domain of FimX (residues 438-686): one of the apo form and the other of a com... |
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Contribution of carboxylesterase in hamster to the intestinal first-pass loss and low bioavailability of ethyl piperate, an effective lipid-lowering drug candidate.
Drug Metab. Dispos. 39(5) , 796-802, (2011) Ethyl piperate is an effective lipid-lowering drug candidate synthesized from piperine. However, its pharmacokinetic characteristics and oral absorption process remain unclear. A liquid chromatography-tandem mass spectrometry method was applied to determine t... |