L-Serine O-sulfate potassium salt
L-Serine O-sulfate potassium salt structure
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Common Name | L-Serine O-sulfate potassium salt | ||
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| CAS Number | 17436-02-1 | Molecular Weight | 223.24600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C3H6KNO6S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Sulphur-containing amino acids are agonists for group 1 metabotropic receptors expressed in clonal RGT cell lines.
Neuropharmacology 37 , 277-287, (1998) Comparison of the pharmacological effects of a range of sulphur-containing amino acids on human mGluR1alpha and mGluR5a has been undertaken. cDNAs of each mGluR were transfected into a Syrian hamster tumour cell line AV12-664 that was previously transfected w... |
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Effects of glutamate transporter inhibitors on the antitumor activity of doxorubicin.
Clin. Cancer Res. 8(12) , 3943-7, (2002) Dihydrokainate, a glutamate transporter inhibitor, was previously found to be a useful modulator of antitumor activity of doxorubicin (DOX). Dihydrokainate prevented an efflux of DOX by inhibiting the uptake of glutamate by tumor cells. We examined the potent... |
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The mechanism of high-yielding chiral syntheses catalysed by wild-type and mutant forms of aspartate aminotransferase.
Eur. J. Biochem. 240(1) , 150-5, (1996) The ability of aspartate aminotransferase to catalyse beta-elimination of alpha-amino acids that have a good leaving group at C beta has been exploited in the synthesis of novel amino acids by the inclusion of appropriate nucleophiles as co-substrates. Two co... |
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Characterization of Na+-coupled glutamate/aspartate transport by a rat brain astrocyte line expressing GLAST and EAAC1.
J. Membr. Biol. 182(1) , 17-30, (2001) D-aspartate (D-Asp) uptake by suspensions of cerebral rat brain astrocytes (RBA) maintained in long-term culture was studied as a means of characterizing function and regulation of Glutamate/Aspartate (Glu/Asp) transporter isoforms in the cells. A-asp influx ... |
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Purification and characterization of human brain serine racemase expressed in moderately halophilic bacteria.
Protein Pept. Lett. 16(2) , 201-6, (2009) We have successfully expressed an active human brain serine racemase (hSR) with His-tag using moderate halophile. The purified His-hSR showed high elimination and racemization activities on L-serine: the elimination activity was 2.6-fold higher than racemizat... |
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Metabolism of sulfur-containing amino acids in the dermatophyte Microsporum gypseum. II. Acidic amino acid derivatives.
J. Basic Microbiol. 25(2) , 111-8, (1985) The dermatophyte Microsporum gypseum was cultivated on a glucose-arginine medium supplemented with five strongly acidic derivatives of cysteine (L-cysteine sulfinic acid, L-cysteic acid, L-serine-O-sulfate and taurine at a concentration of 5 mmol/l, and L-S-s... |
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Serine-O-sulphate transport by the human glutamate transporter, EAAT2.
Br. J. Pharmacol. 123(8) , 1593-600, (1998) 1. Expression of the recombinant human excitatory amino aid transporters, EAAT1 and EAAT2, in Xenopus laevis oocytes allows electrogenic transport to be studied under voltage clamp conditions. 2. We have investigated the transport of the pharmacological subst... |
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Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2.
J. Biol. Chem. 273(24) , 14698-706, (1998) Glutamate transporters serve the important function of mediating removal of glutamate released at excitatory synapses and maintaining extracellular concentrations below excitotoxic levels. Excitatory amino acid transporter subtypes EAAT1 and EAAT2 have a high... |
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Crystallographic and chemical studies on cytosolic aspartate aminotransferase.
Prog. Clin. Biol. Res. 144B , 171-93, (1984)
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The roles of Tyr70 and Tyr225 in aspartate aminotransferase assessed by analysing the effects of mutations on the multiple reactions of the substrate analogue serine o-sulphate.
Eur. J. Biochem. 232(3) , 859-64, (1995) Aspartate aminotransferase catalyses multiple reactions of the glutamate analogue, serine O-sulphate. The predominant reaction is beta-elimination of sulphate to give aminoacrylate (kcat = 13 s-1 for the Escherichia coli enzyme) which may either hydrolyse to ... |