2-(Trifluoromethyl)oxirane

2-(Trifluoromethyl)oxirane Structure
2-(Trifluoromethyl)oxirane structure
Common Name 2-(Trifluoromethyl)oxirane
CAS Number 143142-90-9 Molecular Weight 112.050
Density 1.4±0.1 g/cm3 Boiling Point 33.5±35.0 °C at 760 mmHg
Molecular Formula C3H3F3O Melting Point N/A
MSDS Chinese USA Flash Point -21.3±21.8 °C
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger

Discovery of a simple picomolar inhibitor of cholesteryl ester transfer protein.

J. Med. Chem. 46 , 2152, (2003)

A novel series of substituted N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)-trifluoro-3-amino-2-propanols is described which potently and reversibly inhibit cholesteryl ester transfer protein (CETP). Starting from the initial lead 1, various sub...