5-Iodouridine
5-Iodouridine structure
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Common Name | 5-Iodouridine | ||
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| CAS Number | 1024-99-3 | Molecular Weight | 370.10 | |
| Density | 2.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C9H11IN2O6 | Melting Point | 205-207ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Loss of Foxm1 Results in Reduced Somatotrope Cell Number during Mouse Embryogenesis.
PLoS ONE 10 , e0128942, (2015) FOXM1, a member of the forkhead box transcription factor family, plays a key role in cell cycling progression by regulating the expression of critical G1/S and G2/M phase transition genes. In vivo studies reveal that Foxm1 null mice have a 91% lethality rate ... |
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Synthesis of uridine phosphoramidite analogs: reagents for site-specific incorporation of photoreactive sites into RNA sequences.
Bioconjug. Chem. 5(6) , 508-12, (1994) The synthesis of three new photoactive RNA phosphoramidites, 5-bromouridine, 5-iodouridine, and O4-triazolouridine, is reported. The 5' OH of bromouridine and iodouridine were protected as dimethoxytrityl ether using dimethoxytrityl chloride and pyridine. Sel... |
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Phosphine containing oligonucleotides for the development of metallodeoxyribozymes.
Chem. Commun. (Camb.) (15) , 1556-8, (2007) Novel transition metal catalysts based on oligonucleotides can be easily obtained by functionalization of 5-iodouridine with phosphine ligands, resulting in good asymmetric induction in palladium catalyzed allylic nucleophilic substitution. |
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Crosslinking of an iodo-uridine-RNA hairpin to a single site on the human U1A N-terminal RNA binding domain.
RNA 1(1) , 55-63, (1995) The N-terminal RNA binding domain (RBD) of the human U1A snRNP protein binds tightly and specifically to an RNA hairpin that contains a 10-nucleotide loop. The protein is one of a class of RNA binding proteins that adopts a beta alpha beta beta alpha beta glo... |
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X-ray crystallography of large RNAs: heavy-atom derivatives by RNA engineering.
RNA 2(12) , 1295-305, (1996) For small RNAs, isomorphous heavy-atom derivatives can be obtained by crystallizing synthetic versions that incorporate modified nucleotides such as iodo- or bromouridine. However, such a synthetic approach is not yet feasible for RNAs greater than approximat... |
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New tertiary constraints between the RNA components of active yeast spliceosomes: a photo-crosslinking study.
RNA 10(8) , 1251-65, (2004) Elucidation of the three-dimensional (3D) structures of the two sequential active sites in spliceosomes is essential for understanding the mechanism of premessenger RNA splicing. The mechanism is predicted to be catalyzed by the small nuclear RNA (snRNA) comp... |
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Laser-induced photo-cross-linking of cisplatin-modified DNA to HMG-domain proteins.
Biochemistry 40(25) , 7533-41, (2001) Laser-induced photo-cross-linking was investigated for DNA, modified with cisplatin at specific sites, bound to structure-specific recognition domains of proteins in the high-mobility group (HMG) class. The efficiency of photo-cross-linking depends on the wav... |
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Virus-induced thymidine kinases as markers for typing herpes simplex viruses and for drug sensitivity assays.
J. Virol. Methods 5(3-4) , 209-17, (1982) A rapid, reproducible and objective new method for typing herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) based on the effects of virus-induced thymidine kinases on various antiviral drugs has been developed. When several laboratory strains and clini... |
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Low-frequency vibrations of a nucleoside analog.
J. Biomol. Struct. Dyn. 12(2) , 401-11, (1994) This paper reports on the first coherent neutron scattering measurements ever carried out on the vibrational spectrum of a nucleoside analog. Frequencies up to 3.5 Thz belonging to some half-dozen dispersion curves have been measured in a plane normal to the ... |
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Dehalogenation reactions in fast atom bombardment mass spectrometry.
Anal. Chem. 56(11) , 1975-7, (1984)
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