Cocarboxylase
Cocarboxylase structure
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Common Name | Cocarboxylase | ||
|---|---|---|---|---|
| CAS Number | 154-87-0 | Molecular Weight | 460.767 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H19ClN4O7P2S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Regulation at multiple levels control the expression of folate transporters in liver cells in conditions of ethanol exposure and folate deficiency.
Biofactors 41 , 232-41, (2015) Complex regulatory mechanisms control the expression of folate transporters within cells. Liver is the primary reserve of the folate stores within the body. As excessive alcohol consumption or inefficient dietary folate intake are known to create folate defic... |
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The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy.
Drug Metab. Dispos. 42(10) , 1656-62, (2014) The clinical development of fedratinib, a Janus kinase (JAK2) inhibitor, was terminated after reports of Wernicke's encephalopathy in myelofibrosis patients. Since Wernicke's encephalopathy is induced by thiamine deficiency, investigations were conducted to p... |
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Gene Transfer Efficiency in Gonococcal Biofilms: Role of Biofilm Age, Architecture, and Pilin Antigenic Variation.
J. Bacteriol. 197 , 2422-31, (2015) Extracellular DNA is an important structural component of many bacterial biofilms. It is unknown, however, to which extent external DNA is used to transfer genes by means of transformation. Here, we quantified the acquisition of multidrug resistance and visua... |
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Structural insights into WcbI, a novel polysaccharide-biosynthesis enzyme.
IUCrJ 1 , 28-38, (2014) Capsular polysaccharides (CPSs) are protective structures on the surfaces of many Gram-negative bacteria. The principal CPS of the human pathogen and Tier 1 select agent Burkholderia pseudomallei consists of a linear repeat of --3)--2-O-acetyl-6-deoxy-β-d-man... |
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Engineering of yeast pyruvate decarboxylase for enhanced selectivity towards carboligation.
Bioresour. Technol. 192 , 90-6, (2015) The aim of the study was to increase production of (R)-PAC by altering carboligation activity of Pdc in Saccharomyces cerevisiae. Pdc1 activity was modified by over-expression as well as changing the rate of decarboxylation and carboligation by site specific ... |
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Early and persistent abnormal decoding by glial cells at the neuromuscular junction in an ALS model.
J. Neurosci. 35(2) , 688-706, (2015) Amyotrophic lateral sclerosis (ALS) is a late-onset neuromuscular disease characterized by progressive loss of motor neurons (MNs) preceded by neuromuscular junction (NMJ) denervation. Despite the importance of NMJ denervation in ALS, the mechanisms involved ... |
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Energy Conservation Associated with Ethanol Formation from H2 and CO2 in Clostridium autoethanogenum Involving Electron Bifurcation.
J. Bacteriol. 197 , 2965-80, (2015) Most acetogens can reduce CO2 with H2 to acetic acid via the Wood-Ljungdahl pathway, in which the ATP required for formate activation is regenerated in the acetate kinase reaction. However, a few acetogens, such as Clostridium autoethanogenum, Clostridium lju... |
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Simultaneous quantification of 21 water soluble vitamin circulating forms in human plasma by liquid chromatography-mass spectrometry.
J. Chromatogr. A. 1422 , 89-98, (2015) This manuscript reports a validated analytical approach for the quantification of 21 water soluble vitamins and their main circulating forms in human plasma. Isotope dilution-based sample preparation consisted of protein precipitation using acidic methanol en... |
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The detrimental effects of acute hyperglycemia on myocardial glucose uptake.
Life Sci. 105(1-2) , 31-42, (2014) Although acute hyperglycemic (AHG) episodes are linked to lower glucose uptake, underlying mechanisms remain unclear. We hypothesized that AHG triggers reactive oxygen species (ROS) production and increases non-oxidative glucose pathway (NOGP) activation, i.e... |
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Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198.
Cancer Res. 75 , 4790-802, (2015) Isocitrate dehydrogenase 1 (IDH1) is mutated in various types of human cancer to IDH1(R132H), a structural alteration that leads to catalysis of α-ketoglutarate to the oncometabolite D-2-hydroxyglutarate. In this study, we present evidence that small-molecule... |