Cocarboxylase

Modify Date: 2024-01-02 19:04:10

Cocarboxylase Structure
Cocarboxylase structure
 Common Name Cocarboxylase
CAS Number 154-87-0 Molecular Weight 460.767
Density N/A Boiling Point N/A
Molecular Formula C12H19ClN4O7P2S Melting Point N/A
MSDS USA Flash Point N/A

 Use of Cocarboxylase


Thiamine pyrophosphate is the coenzyme form of Vitamin B1 and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.

 Names

Name thiamine(1+) diphosphate
Synonym More Synonyms

 Cocarboxylase Biological Activity

Description Thiamine pyrophosphate is the coenzyme form of Vitamin B1 and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.
Related Catalog
Target

Human Endogenous Metabolite

 Chemical & Physical Properties

Molecular Formula C12H19ClN4O7P2S
Molecular Weight 460.767
Exact Mass 460.013824
PSA 216.83000
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XI7552000
CHEMICAL NAME :
Thiamine, trihydrogen pyrophosphate (ester)
CAS REGISTRY NUMBER :
154-87-0
LAST UPDATED :
199806
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C12-H19-N4-O7-P2-S.Cl
MOLECULAR WEIGHT :
460.80
WISWESSER LINE NOTATION :
T6N CNJ B1 DZ E1- AT5K CSJ D2OPQO&OPQQO E1 &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,471,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
465 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,471,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,1025,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,471,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
360 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,471,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,1025,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3828 No. of Facilities: 172 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 850 (estimated) No. of Female Employees: 766 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Risk Phrases R22
Safety Phrases S22-S24/25
RIDADR 1759
WGK Germany 3
RTECS XI7552000
Packaging Group III
Hazard Class 8

 Synthetic Route

thiamin triphosphate structure

thiamin triphosphate

CAS#:50851-39-3
Thiamine hydrochloride structure

Thiamine hydroc...

CAS#:67-03-8

~%

Cocarboxylase Structure

Cocarboxylase

CAS#:154-87-0

3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]thiazolium structure

3-[(4-Amino-2-m...

CAS#:10023-48-0
Literature: Justus Liebigs Annalen der Chemie, , vol. 618, p. 210,215, 219 Yakugaku Zasshi, , vol. 76, p. 1314,1317 Chem.Abstr., , p. 3607 Helvetica Chimica Acta, , vol. 32, p. 1478,1483 Journal of Vitaminology, , vol. 5, p. 44,49
N/A structure

N/A

CAS#:4066-53-9

~%

Cocarboxylase Structure

Cocarboxylase

CAS#:154-87-0
Literature: Chemische Berichte, , vol. 95, p. 767 - 772
Thiamine diphosphate analog 1 structure

Thiamine diphos...

CAS#:2606-90-8
4-Pyrimidinamine, 5-(bromomethyl)-2-methyl-, monohydrobromide structure

4-Pyrimidinamin...

CAS#:2908-71-6

~%

Cocarboxylase Structure

Cocarboxylase

CAS#:154-87-0
Literature: Chemische Berichte, , vol. 95, p. 767 - 772

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 Synonyms

3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium chloride
TDP
Vitamin B1 Pyrophosphoric Acid Ester Chloride
3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-[2-[[hydroxy(phosphonooxy)phosphinyl]oxy]ethyl]-4-methylthiazolium Chloride
3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium chloride
Cocarboxylase
MFCD00038740
3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-3,5-dioxa-4,6-diphosphahex-1-yl)thiazolium Chloride P,P'-Dioxide
cocarboxylasum [INN_la]
Vitamin B1 Pyrophosphate Chloride
Thiamine pyrophosphate
Aneurinepyrophosphoric acid Cocarboxylase Thiamine pyrophosphate chloride
3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-4,6-dioxido-3,5-dioxa-4,6-diphosphahex-1-yl)thiazolium Chloride
Co-B1
tpp
EINECS 205-230-7
Bioxilasi
thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-[2-[[hydroxy(phosphonooxy)phosphinyl]oxy]ethyl]-4-methyl-, chloride (1:1)
TPP (VAN)
Thiamine Pyrophosphoric Acid Ester Chloride
Thiamine Pyrophosphate Chloride
thiamine(1+) diphosphate chloride
Thiamine Diphosphate Ester Chloride
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Related Compounds: More...
Cocarboxylase [INN]
136-08-3
Cocarboxylase tetrahydrate
68684-55-9
Chemsrc provides Cocarboxylase(CAS#:154-87-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Cocarboxylase are included as well.>> amp version: Cocarboxylase

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