Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Cocarboxylase
Price: ￥328.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Cocarboxylase
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Cocarboxylase
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Cocarboxylase hydrochloride, powder (API)
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

154-87-0

154-87-0 structure

Name: Cocarboxylase
Chemical Name: thiamine(1+) diphosphate
CAS Number: 154-87-0
Molecular Formula: C₁₂H₁₉ClN₄O₇P₂S
Molecular Weight: 460.767
Catalog: API Vitamins and minerals Vitamin B drugs
Create Date: 2018-04-26 08:00:00
Modify Date: 2024-01-02 19:04:10
Thiamine pyrophosphate is the coenzyme form of Vitamin B1 and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.

Name	thiamine(1+) diphosphate
Synonyms	3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium chloride TDP Vitamin B1 Pyrophosphoric Acid Ester Chloride 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-[2-[[hydroxy(phosphonooxy)phosphinyl]oxy]ethyl]-4-methylthiazolium Chloride 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium chloride Cocarboxylase MFCD00038740 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-3,5-dioxa-4,6-diphosphahex-1-yl)thiazolium Chloride P,P'-Dioxide cocarboxylasum [INN_la] Vitamin B1 Pyrophosphate Chloride Thiamine pyrophosphate Aneurinepyrophosphoric acid Cocarboxylase Thiamine pyrophosphate chloride 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-4,6-dioxido-3,5-dioxa-4,6-diphosphahex-1-yl)thiazolium Chloride Co-B1 tpp EINECS 205-230-7 Bioxilasi thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-[2-[[hydroxy(phosphonooxy)phosphinyl]oxy]ethyl]-4-methyl-, chloride (1:1) TPP (VAN) Thiamine Pyrophosphoric Acid Ester Chloride Thiamine Pyrophosphate Chloride thiamine(1+) diphosphate chloride Thiamine Diphosphate Ester Chloride

Description	Thiamine pyrophosphate is the coenzyme form of Vitamin B1 and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.
Related Catalog	Natural Products >> Others Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite

Molecular Formula	C₁₂H₁₉ClN₄O₇P₂S
Molecular Weight	460.767
Exact Mass	460.013824
PSA	216.83000
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XI7552000

CHEMICAL NAME :: Thiamine, trihydrogen pyrophosphate (ester)

CAS REGISTRY NUMBER :: 154-87-0

LAST UPDATED :: 199806

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C12-H19-N4-O7-P2-S.Cl

MOLECULAR WEIGHT :: 460.80

WISWESSER LINE NOTATION :: T6N CNJ B1 DZ E1- AT5K CSJ D2OPQO&OPQQO E1 &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,471,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 465 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,471,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,1025,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,471,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,471,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,1025,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3828 No. of Facilities: 172 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 850 (estimated) No. of Female Employees: 766 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Risk Phrases	R22
Safety Phrases	S22-S24/25
RIDADR	1759
WGK Germany	3
RTECS	XI7552000
Packaging Group	III
Hazard Class	8

50851-39-3

67-03-8

154-87-0

10023-48-0

Literature: Justus Liebigs Annalen der Chemie, , vol. 618, p. 210,215, 219 Yakugaku Zasshi, , vol. 76, p. 1314,1317 Chem.Abstr., , p. 3607 Helvetica Chimica Acta, , vol. 32, p. 1478,1483 Journal of Vitaminology, , vol. 5, p. 44,49

4066-53-9

154-87-0

Literature: Chemische Berichte, , vol. 95, p. 767 - 772

2606-90-8

2908-71-6

154-87-0

Literature: Chemische Berichte, , vol. 95, p. 767 - 772

Precursor 3
50851-39-3 67-03-8 2908-71-6
DownStream 1
532-40-1