Phenothiazine
Phenothiazine structure
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Common Name | Phenothiazine | ||
|---|---|---|---|---|
| CAS Number | 92-84-2 | Molecular Weight | 199.272 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 371.0±12.0 °C at 760 mmHg | |
| Molecular Formula | C12H9NS | Melting Point | 184 °C | |
| MSDS | Chinese USA | Flash Point | 178.2±19.6 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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The EpiOcular Eye Irritation Test (EIT) for hazard identification and labelling of eye irritating chemicals: protocol optimisation for solid materials and the results after extended shipment.
Altern. Lab. Anim. 43 , 101-27, (2015) The 7th Amendment to the EU Cosmetics Directive and the EU REACH Regulation have reinforced the need for in vitro ocular test methods. Validated in vitro ocular toxicity tests that can predict the human response to chemicals, cosmetics and other consumer prod... |
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Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins
Bioorg. Med. Chem. 17 , 896-904, (2009) This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the mole... |
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Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification o... |
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify comp... |
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The novel semi-biodegradable interpenetrating polymer networks based on urethane-dimethacrylate and epoxy-polyester components as alternative biomaterials.
Acta Bioeng. Biomech. 17 , 13-22, (2015) This paper presents the pilot study aimed at the development of new full interpenetrating polymer networks based on urethane- dimethacrylate and biodegradable epoxy-polyester as the proposition of new biomaterials with gradually emerging porosity.The urethane... |
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Facile synthesis and photo-physical properties of cyano-substituted styryl derivatives based on carbazole/phenothiazine
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 95 , 128-34, (2012) Graphical abstract |
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Free-radical-scavenging effect of carbazole derivatives on AAPH-induced hemolysis of human erythrocytes.
Bioorg. Med. Chem. 15 , 1903-13, (2007) Since the research on antioxidants provides theoretical information for the medicinal development, and supplies some in vitro methods for quick-optimizing drugs, it attracts more scientific attention from bioorganic and medicinal chemists. In addition to the ... |
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Characterization of mixtures of compounds produced in chlorpromazine aqueous solutions by ultraviolet laser irradiation: their applications in antimicrobial assays.
J. Biomed. Opt. 20 , 051002, (2014) The study reports an investigation of the photoproducts obtained by exposure of chlorpromazine hydrochloride in ultrapure water (concentration 2 mg/mL) to a 266-nm laser beam obtained by fourth harmonic generation from a Nd:YAG laser (6-ns full time width at ... |
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[Effect of potassium phenosan on structure of plasma membranes of mice liver cells in vitro].
Biofizika 58(1) , 97-105, (2013) The effect of synthetic anti-oxidant potassium phenosan (PP, potassium salt of beta-(4-hydroxy-3,5-ditretbutil-phenyl)-propionic acid) on the structural state of the surface (8 angstroms) and deep (20-22 angstroms) lipid regions of plasma membranes of mice li... |