Phenothiazine

Modify Date: 2024-01-01 20:53:39

Phenothiazine Structure
Phenothiazine structure
 Common Name Phenothiazine
CAS Number 92-84-2 Molecular Weight 199.272
Density 1.2±0.1 g/cm3 Boiling Point 371.0±12.0 °C at 760 mmHg
Molecular Formula C12H9NS Melting Point 184 °C
MSDS Chinese USA Flash Point 178.2±19.6 °C
Symbol GHS07 GHS08
GHS07, GHS08		 Signal Word Warning

 Use of Phenothiazine


Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases[1][2].

 Names

Name 10H-phenothiazine
Synonym More Synonyms

 Phenothiazine Biological Activity

Description Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases[1][2].
Related Catalog
References

[1]. Mitchell SC, et, al. The toxicity of phenothiazine. Drug Metabol Drug Interact. 1994;11(3):201-35.

[2]. Ohlow MJ, et, al. Phenothiazine: the seven lives of pharmacology's first lead structure. Drug Discov Today. 2011 Feb;16(3-4):119-31.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 371.0±12.0 °C at 760 mmHg
Melting Point 184 °C
Molecular Formula C12H9NS
Molecular Weight 199.272
Flash Point 178.2±19.6 °C
Exact Mass 199.045563
PSA 37.33000
LogP 4.15
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.675
Stability Stable. Combustible. Incompatible with strong oxidizing agents, strong acids. May discolour upon exposure to light.
Water Solubility 2 mg/L (25 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SN5075000
CHEMICAL NAME :
Phenothiazine
CAS REGISTRY NUMBER :
92-84-2
BEILSTEIN REFERENCE NO. :
0143237
LAST UPDATED :
199712
DATA ITEMS CITED :
28
MOLECULAR FORMULA :
C12-H9-N-S
MOLECULAR WEIGHT :
199.28
WISWESSER LINE NOTATION :
T C666 BM ISJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
425 mg/kg/5D
TOXIC EFFECTS :
Behavioral - headache Liver - jaundice, other or unclassified Blood - normocytic anemia
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 242,86,1942
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Behavioral - antipsychotic
REFERENCE :
DNEUD5 Developments in Neuroscience (Amsterdam). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 7,45,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
178 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00586
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1104,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cattle
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1104,1986
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 66,888,1944 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1250 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception
REFERENCE :
AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-192, 1901-91. Volume(issue)/page/year: 110,29,1962 *** REVIEWS *** ACGIH TLV-TWA 5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW PLMJAP Pahlavi Medical Journal. (Shiraz, Iran) V.1-9, 1970-78. Volume(issue)/page/year: 6,160,1975 TOXICOLOGY REVIEW CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955- Volume(issue)/page/year: 19,361,1973 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,204,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 5 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 5 mg/m3;Skin JAN 1993 OEL-FINLAND:TWA 5 mg/m3;STEL 10 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 5 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 mg/m3;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 5 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHENOTHIAZINE-air:10H TWA 5 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84116 No. of Facilities: 175 (estimated) No. of Industries: 5 No. of Occupations: 15 No. of Employees: 5639 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84116 No. of Facilities: 5473 (estimated) No. of Industries: 54 No. of Occupations: 68 No. of Employees: 88048 (estimated) No. of Female Employees: 8791 (estimated)

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H302-H317-H373-H412
Precautionary Statements P273-P280
Target Organs Blood
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi:Irritant;N:Dangerousfortheenvironment;
Risk Phrases R36/38;R43;R51/53
Safety Phrases S26-S36-S61-S36/37/39-S29
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS SN5075000
HS Code 29343090

 Synthetic Route

 Customs

HS Code 2934300000
Summary 2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles55

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 Synonyms

Thiodiphenylamine
Dibenzothiazine
Phenosan
EINECS 202-196-5
Antiverm
Phenthiazine
Agrazine
PHENOTHIAZINE
Feeno
MFCD00005015
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Related Compounds: More...
phenothiazine
262-20-4
1H-phenothiazine
261-86-9
azaphenothiazine
261-92-7
Acylphenothiazine
13420-96-7
benzophenothiazine
28453-74-9
benzophenothiazine
225-83-2
phenothiazine-3-one
581-30-6
dibenzophenothiazine
226-52-8
2-vinylphenothiazine
21896-43-5
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