Phorbol 12,13-diacetate

Phorbol 12,13-diacetate Structure
Phorbol 12,13-diacetate structure
Common Name Phorbol 12,13-diacetate
CAS Number 24928-15-2 Molecular Weight 448.50600
Density 1.34g/cm3 Boiling Point 585.7ºC at 760 mmHg
Molecular Formula C24H32O8 Melting Point N/A
MSDS Chinese USA Flash Point 195.4ºC
Symbol GHS06
GHS06
Signal Word Danger

Light-dependent translocation of arrestin in rod photoreceptors is signaled through a phospholipase C cascade and requires ATP.

Cell. Signal. 22(3) , 447-56, (2010)

Partitioning of cellular components is a critical mechanism by which cells can regulate their activity. In rod photoreceptors, light induces a large-scale translocation of arrestin from the inner segments to the outer segments. The purpose of this project is ...

VNN1, a potential biomarker for pancreatic cancer-associated new-onset diabetes, aggravates paraneoplastic islet dysfunction by increasing oxidative stress.

Cancer Lett. 373 , 241-50, (2016)

In our previous clinical microarray analysis, we were the first to report on Vanin-1 (VNN1) as a novel clinically derived biomarker of pancreatic cancer-associated new-onset diabetes (PCAND). The functional mechanisms of VNN1 in the pathogenesis of PCAND, how...

An improved model of predicting hepatocarcinogenic potential in rats by using gene expression data.

J. Appl. Toxicol. 36 , 296-308, (2016)

Carcinogenicity studies using animals are expensive and time consuming. Therefore, the development of a highly accurate carcinogenicity prediction system to interpret short-term test results would be beneficial. The Ames test is popular for mutagens; however,...

Expansive Phenotypic Landscape of Botrytis cinerea Shows Differential Contribution of Genetic Diversity and Plasticity.

Mol. Plant Microbe Interact. 29 , 287-98, (2016)

The modern evolutionary synthesis suggests that both environmental variation and genetic diversity are critical determinants of pathogen success. However, the relative contribution of these two sources of variation is not routinely measured. To estimate the r...

Modulation of human neutrophil oxidative metabolism and degranulation by extract ofTamarindus indicaL. fruit pulp

Food Chem. Toxicol. 47 , 163-70, (2009)

The tamarind ( Tamarindus indica L .) is indigenous to Asian countries and widely cultivated in the American continents. The tamarind fruit pulp extract (ExT), traditionally used in spices, food components and juices, is rich in polyphenols that have demonstr...

Combinational enhancing effects of formulation and encapsulation on digestive stability and intestinal transport of green tea catechins.

J. Microencapsul. 33 , 183-90, (2016)

The hypothesis was that green tea catechins (GTCs) formulated with vitamin C and xylitol followed by enteric coating with hydroxypropyl methyl cellulose phthalate (HPMCP) or encapsulated into γ-cyclodextrin (γ-CD) could enhance intestinal absorption of GTCs. ...

Development of Microsatellite Markers and Analysis of Genetic Diversity and Population Structure of Colletotrichum gloeosporioides from Ethiopia.

PLoS ONE 11 , e0151257, (2016)

Twenty three polymorphic microsatellite markers were developed for citrus plant pathogenic fungus, Colletotrichum gloeosporioides, and were used to analyze genetic diversity and population structure of 163 isolates from four different geographical regions of ...

Characterization of aflatoxigenic Aspergillus flavus and A. parasiticus strain isolates from animal feedstuffs in northeastern Iran.

Iran J Vet Res 16 , 150-5, (2016)

Aflatoxins are secondary toxic metabolites produced by some Aspergillus spp. particularly, Aspergillus flavus and A. parasiticus that contaminate food and feed. The objective of this study was to evaluate the contamination of feedstuffs with Aspergillus spp. ...

Antifungal activity of extracts from Atacama Desert fungi against Paracoccidioides brasiliensis and identification of Aspergillus felis as a promising source of natural bioactive compounds.

Mem. Inst. Oswaldo Cruz 111 , 209-17, (2016)

Fungi of the genus Paracoccidioides are responsible for paracoccidioidomycosis. The occurrence of drug toxicity and relapse in this disease justify the development of new antifungal agents. Compounds extracted from fungal extract have showing antifungal activ...

Involvement of Fungal Pectin Methylesterase Activity in the Interaction Between Fusarium graminearum and Wheat.

Mol. Plant Microbe Interact. 29 , 258-67, (2016)

The genome of Fusarium graminearum, the causal agent of Fusarium head blight of wheat, contains two putative pectin methylesterase (PME)-encoding genes. However, when grown in liquid culture containing pectin, F. graminearum produces only a single PME, which ...