Acetonylacetone
Acetonylacetone structure
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Common Name | Acetonylacetone | ||
|---|---|---|---|---|
| CAS Number | 110-13-4 | Molecular Weight | 114.142 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 188.8±13.0 °C at 760 mmHg | |
| Molecular Formula | C6H10O2 | Melting Point | −6-−5 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 78.9±0.0 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Escherichia coli kduD encodes an oxidoreductase that converts both sugar and steroid substrates.
Appl. Microbiol. Biotechnol. 98(12) , 5471-85, (2014) A previously unidentified oxidoreductase from Escherichia coli catalyzes the regioselective reduction of eukaryotic steroid hormone 11-deoxycorticosterone (11-DOC) to the valuable bioactive product 4-pregnen-20,21-diol-3-one. In nature, a reduction of C-20 ca... |
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2,5-hexanedione altered the degradation of low-molecular-weight neurofilament in rat nerve tissues.
Food Chem. Toxicol. 50(12) , 4277-84, (2012) Occupational exposure to n-hexane produces a central-peripheral distal axonopathy, which is characterized by giant axonal swellings filled with neurofilaments (NFs). To investigate the change of NFs degradation and their possible role in n-hexane neuropathy, ... |
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Alternative biomarkers of n-hexane exposure: characterization of aminoderived pyrroles and thiol-pyrrole conjugates in urine of rats exposed to 2,5-hexanedione.
Toxicol. Lett. 224(1) , 54-63, (2014) The identification of pyrrole derivatives in urine of rats exposed to 2,5-hexanedione (2,5-HD), was performed to select an adequate peripheral biomarker predictive of 2,5-HD neurotoxicity. Studies on molecular mechanism of 2,5-HD neurotoxicity have revealed t... |
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Toxicity and metabolism of the neurotoxic hexacarbons n-hexane, 2-hexanone, and 2,5-hexanedione.
Annu. Rev. Pharmacol. Toxicol. 22 , 145-66, (1982) Human exposure to hexacarbon compounds is quite pervasive, including occupational exposures to industrial solvents as well as unintentional and sometimes deliberate exposures to hexacarbon solvents contained in innumerable commercial products. The exact mecha... |
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Role of N-acetylcysteine in protecting against 2,5-hexanedione neurotoxicity in a rat model: changes in urinary pyrroles levels and motor activity performance.
Environ. Toxicol. Pharmacol. 38(3) , 807-13, (2014) The interference of N-acetylcysteine (NAC) on 2,5-hexanedione (2,5-HD) neurotoxicity was evaluated through behavioral assays and the analysis of urinary 2,5-HD, dimethylpyrrole norleucine (DMPN), and cysteine-pyrrole conjugate (DMPN NAC), by ESI-LC-MS/MS, in ... |
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Exposure to 2,5-hexanedione can induce neural malformations in chick embryos.
Neurotoxicology 33(5) , 1239-47, (2012) Worldwide, n-hexane is an organic solvent widely used in numerous industries such as chemical engineering, pharmaceutical and cosmetic industry. 2,5-Hexanedione (2,5-HD) is the main metabolite of n-hexane. It is now gradually recognized that chronic exposure ... |
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Molecular alterations underlying the enhanced disruption of spermatogenesis by 2,5-hexanedione and carbendazim co-exposure.
Reprod. Toxicol. 33(3) , 382-9, (2012) The current study investigated the co-exposure effects of 2,5-hexanedione (HD) and carbendazim (CBZ) on gene expression underlying the enhanced pathology previously observed. Adult male rats were exposed to HD (0.33 or 1%) followed by CBZ (67 or 200 mg/kg), a... |
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The effect of 2,5-hexanedione on myelin protein zero expression, and its mitigation using Ginkgo biloba extract.
Biomed. Environ. Sci. 24(4) , 374-82, (2011) To investigate the role of myelin protein zero (P(0)) in 2,5-hexanedione (2,5-HD)-induced peripheral nerve injury, and the protective effect of Ginkgo biloba extract (Egb761) on 2,5-HD-induced toxic peripheral neuropathy.After 4 weeks of treatment with 2,5-HD... |
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Optimization of a filter-lysis protocol to purify rat testicular homogenates for automated spermatid counting.
J. Androl. 33(5) , 811-6, (2012) Quantifying testicular homogenization-resistant spermatid heads (HRSH) is a powerful indicator of spermatogenesis. These counts have traditionally been performed manually using a hemocytometer, but this method can be time consuming and biased. We aimed to dev... |
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The effect of 2,5-hexanedione on permeability of blood-nerve barrier in rats.
Hum. Exp. Toxicol. 29(6) , 497-506, (2010) To explore the effect of 2,5-hexanedione on permeability of blood-nerve barrier, adult Wistar rats were administered with 400 mg x kg(-1) x d(- 1) 2,5-hexanedione to establish animal model of 2,5-hexnedione neuropathy. Evans blue was injected through left fem... |