alpha-Asarone
alpha-Asarone structure
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Common Name | alpha-Asarone | ||
|---|---|---|---|---|
| CAS Number | 2883-98-9 | Molecular Weight | 208.254 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 296.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C12H16O3 | Melting Point | 57-61 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 107.7±23.8 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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β-Asarone, an active principle of Acorus calamus rhizome, inhibits morphogenesis, biofilm formation and ergosterol biosynthesis in Candida albicans.
Phytomedicine 20(2) , 139-42, (2013) Anti-Candida potential of Acorus calamus rhizome and its active principle, β-asarone, was evaluated against the human fungal pathogen, Candida albicans. β-Asarone exhibited promising growth inhibitory activity at 0.5mg/ml and it was fungicidal at 8 mg/ml. Tim... |
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Cerebrovascular protection of β-asarone in Alzheimer's disease rats: a behavioral, cerebral blood flow, biochemical and genic study.
J. Ethnopharmacol. 144(2) , 305-12, (2012) Recent studies have suggested that β-asarone have neuroprotective and cardiovascular protective effects in animal model. However, the influence of β-asarone on cerebrovascular system has not been explored so far. Therefore, present study was designed to deter... |
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Simultaneous determination ofα-,β- andγ-asarone inAcorus tatarinowiiby microemulsion electrokinetic chromatography with [BMIM]PF6as oil phase
Talanta 101 , 510-5, (2012) In the present study, a rapid and repeatable microemulsion electrokinetic chromatography (MEEKC) method was developed for the simultaneous determination of three isomers (α-, β- and γ-asarone) in Acorus tatarinowii by using ionic liquid 1-butyl-3-methylimidaz... |
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Terpenoid composition and antifungal activity of three commercially important essential oils against Aspergillus flavus and Aspergillus niger.
Nat. Prod. Res. 25(20) , 1993-8, (2011) Hydro-distilled essential oils extracted from three commercially important aromatic plants were analysed by capillary gas chromatography-flame ionization detector and gas chromatography/quadrupole mass spectrometry and subjected to antifungal activity. Fiftee... |
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Radioprotection by α-asarone: Prevention of genotoxicity and hematopoietic injury in mammalian organism
Mutat. Res. 722(1) , 62-8, (2011) α-Asarone (1-propenyl-2,4,5-methoxybenzol), one of the active components of Acorus calamus extract, was examined for its efficacy as a radioprotector in mice exposed to lethal and sublethal whole-body γ-radiation. Oral administration of α-asarone 1 h prior to... |
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An efficient combination of supercritical fluid extraction and high-speed counter-current chromatography to extract and purify (E)- and (Z)-diastereomers of α-asarone and β-asarone from Acorus tatarinowii Schott.
J. Sep. Sci. 34(23) , 3339-43, (2011) In this study, supercritical fluid extraction (SFE) was used to extract essential oil from Acorus tatarinowii Schott under the pressure of 25 MPa and temperature of 35°C. Two (E)- and (Z)-diastereomers of α-asarone and β-asarone were separated and purified by... |
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Anxiolytic-like effect of α-asarone in mice.
Phytother Res. 26(10) , 1476-81, (2012) The effects of α-asarone in four assays predictive of anxiolytic activity in male mice were studied, with diazepam as a positive anxiolytic control. The use of the elevated plus-maze test revealed that diazepam (2 mg/kg) or α-asarone (3.5 mg/kg) increased the... |
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Beta-asarone inhibits synaptic inputs to airway preganglionic parasympathetic motoneurons.
Respir. Physiol. Neurobiol. 177(3) , 313-9, (2011) Therapeutic application of Asarum, a herbal medicine that has been used for centuries, reportedly causes acute respiratory disturbance. The responsible constituents, the sites of action, and the mechanisms involved in this side effect are unclear. We investig... |
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A rapid HPLC-ESI-MS/MS method for determination of β-asarone, a potential anti-epileptic agent, in plasma after oral administration of Acorus calamus extract to rats.
Biomed. Chromatogr. 27(3) , 318-26, (2013) β-Asarone (BAS), a phenylpropanoid from Acorus calamus Linn., has shown biological effects in the management of cognitive impairment conditions such as Alzheimer's disease. The present paper describes a selective and sensitive liquid chromatography-tandem mas... |
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Development and evaluation of α-asarone transdermal patches based on hot-melt pressure-sensitive adhesives.
AAPS PharmSciTech 14(1) , 294-300, (2013) A hot-melt, pressure-sensitive adhesive (HMPSA) based on styrene-isoprene-styrene was prepared, and its compatibility with various transdermal penetration enhancers was investigated. The effect of penetration enhancers on the adhesion properties of HMPSA was ... |