alpha-Asarone structure
|
Common Name | alpha-Asarone | ||
---|---|---|---|---|
CAS Number | 2883-98-9 | Molecular Weight | 208.254 | |
Density | 1.0±0.1 g/cm3 | Boiling Point | 296.0±0.0 °C at 760 mmHg | |
Molecular Formula | C12H16O3 | Melting Point | 57-61 °C(lit.) | |
MSDS | Chinese USA | Flash Point | 107.7±23.8 °C | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of alpha-AsaroneAlpha-Asarone is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice.IC50 value:Target:In vitro: The results indicated that α-asarone significantly attenuated the LPS-stimulated increase in neuroinflammatory responses and suppressed pro-inflammatory cytokine production in BV-2 cells. Mechanistic study revealed that α-asarone?inhibited the LPS-stimulated activation via regulation of nuclear factor kappa-B by blocking degradation of inhibitor kappa B-alpha signaling in BV-2 microglial cells. [2]In vivo: The present results reveal that the acute treatment of α-asarone elicited biphasic responses on immobility such that the duration of the immobility time is significantly reduced at lower doses (15 and 20 mg/kg, i.p.) but increased at higher doses (50 and 100 mg/kg, i.p.) in the TST. Besides, α-asarone at higher doses (50 and 100 mg/kg, i.p.) significantly decreased the spontaneous locomotor activity.[1] |
Name | α-asarone |
---|---|
Synonym | More Synonyms |
Description | Alpha-Asarone is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice.IC50 value:Target:In vitro: The results indicated that α-asarone significantly attenuated the LPS-stimulated increase in neuroinflammatory responses and suppressed pro-inflammatory cytokine production in BV-2 cells. Mechanistic study revealed that α-asarone?inhibited the LPS-stimulated activation via regulation of nuclear factor kappa-B by blocking degradation of inhibitor kappa B-alpha signaling in BV-2 microglial cells. [2]In vivo: The present results reveal that the acute treatment of α-asarone elicited biphasic responses on immobility such that the duration of the immobility time is significantly reduced at lower doses (15 and 20 mg/kg, i.p.) but increased at higher doses (50 and 100 mg/kg, i.p.) in the TST. Besides, α-asarone at higher doses (50 and 100 mg/kg, i.p.) significantly decreased the spontaneous locomotor activity.[1] |
---|---|
Related Catalog | |
References |
Density | 1.0±0.1 g/cm3 |
---|---|
Boiling Point | 296.0±0.0 °C at 760 mmHg |
Melting Point | 57-61 °C(lit.) |
Molecular Formula | C12H16O3 |
Molecular Weight | 208.254 |
Flash Point | 107.7±23.8 °C |
Exact Mass | 208.109940 |
PSA | 27.69000 |
LogP | 2.98 |
Vapour Pressure | 0.0±0.6 mmHg at 25°C |
Index of Refraction | 1.526 |
Storage condition | −20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
Symbol |
GHS07 |
---|---|
Signal Word | Warning |
Hazard Statements | H302 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
Hazard Codes | Xn: Harmful; |
Risk Phrases | R22 |
Safety Phrases | S22-S24/25 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | DC2975000 |
Packaging Group | II; III |
Hazard Class | 4.1 |
Precursor 8 | |
---|---|
DownStream 5 | |
β-Asarone, an active principle of Acorus calamus rhizome, inhibits morphogenesis, biofilm formation and ergosterol biosynthesis in Candida albicans.
Phytomedicine 20(2) , 139-42, (2013) Anti-Candida potential of Acorus calamus rhizome and its active principle, β-asarone, was evaluated against the human fungal pathogen, Candida albicans. β-Asarone exhibited promising growth inhibitory... |
|
Cerebrovascular protection of β-asarone in Alzheimer's disease rats: a behavioral, cerebral blood flow, biochemical and genic study.
J. Ethnopharmacol. 144(2) , 305-12, (2012) Recent studies have suggested that β-asarone have neuroprotective and cardiovascular protective effects in animal model. However, the influence of β-asarone on cerebrovascular system has not been expl... |
|
Simultaneous determination ofα-,β- andγ-asarone inAcorus tatarinowiiby microemulsion electrokinetic chromatography with [BMIM]PF6as oil phase
Talanta 101 , 510-5, (2012) In the present study, a rapid and repeatable microemulsion electrokinetic chromatography (MEEKC) method was developed for the simultaneous determination of three isomers (α-, β- and γ-asarone) in Acor... |
Benzene, 1,2,4-trimethoxy-5-[(1E)-1-propen-1-yl]- |
trans-1,2,4-Trimethoxy-5-(1-propenyl)benzene |
Asarin |
1,2,4-trimethoxy-5-[(1E)-prop-1-en-1-yl]benzene |
EINECS 220-743-6 |
A-Asarion |
trans-1,2,4-Trimethoxy-5-(1-propenyl)benzene,trans-1-Propenyl-2,4,5-trimethoxybenzene |
Asaron |
alpha-asarone |
(E)-Asarone |
benzene, 1,2,4-trimethoxy-5-[(1E)-1-propenyl]- |
a-Asarone |
α-Asarone |
1,2,4-Trimethoxy-5-[(1E)-1-propen-1-yl]benzene |
ASARONE,A |
MFCD00064457 |
1,2,4-Triméthoxy-5-[(1E)-1-propèn-1-yl]benzène |
trans-Asarone |
trans-2,4,5-trimethoxyphenylpropene |
Asarone |
trans-asaron |
Etherophenol |