5-hydroxy Thiabendazole
5-hydroxy Thiabendazole structure
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Common Name | 5-hydroxy Thiabendazole | ||
|---|---|---|---|---|
| CAS Number | 948-71-0 | Molecular Weight | 217.25 | |
| Density | 1.535g/cm3 | Boiling Point | 525.6ºC at 760mmHg | |
| Molecular Formula | C10H7N3OS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 271.7ºC | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Multi-residue Determination of Polar Veterinary Drugs in Livestock and Fishery Products by Liquid Chromatography/Tandem Mass Spectrometry.
J. AOAC Int. 98(1) , 230-47, (2015) Residues of 37 polar veterinary drugs belonging to six families (quinolones, tetracyclines, macrolides, lincosamides, sulfonamides, and others) in livestock and fishery products were determined using a validated LC-MS/MS method. There were two key points in s... |
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Evidence for cytochrome P4501A2-mediated protein covalent binding of thiabendazole and for its passive intestinal transport: use of human and rabbit derived cells.
Chem. Biol. Interact. 127(2) , 109-24, (2000) Thiabendazole (TBZ), an anthelmintic and fungicide benzimidazole, was recently demonstrated to be extensively metabolized by cytochrome P450 (CYP) 1A2 in man and rabbit, yielding 5-hydroxythiabendazole (5OH-TBZ), the major metabolite furtherly conjugated, and... |
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In vitro and in silico identification and characterization of thiabendazole as a mechanism-based inhibitor of CYP1A2 and simulation of possible pharmacokinetic drug-drug interactions.
Drug Metab. Dispos. 37 , 1286-1294, (2009) Thiabendazole (TBZ) and its major metabolite 5-hydroxythiabendazole (5OH-TBZ) were screened for potential time-dependent inhibition (TDI) against CYP1A2. Screen assays were carried out in the absence and presence of NADPH. TDI was observed with both compounds... |
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[Distribution and elimination of thiabendazole and its metabolite residue in laying hens].
Wei Sheng Yan Jiu 40(3) , 365-7, 374, (2011) To explore the distribution and elimination of thiabendazole and its metabolite 5-hydrothiabendazole residues in the hens tissues including liver, muscle, heart, fat, as well as in eggs.Laying hens were orally administred thiabendazole for 5 consecutive days ... |
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Determination of thiabendazole, 5-hydroxythiabendazole, fenbendazole, and oxfendazole in milk.
J. Assoc. Off. Anal. Chem. 73(3) , 368-73, (1990) The liquid chromatographic determination previously developed for benzimidazoles in cattle liver has been slightly modified and applied to the determination of 4 benzimidazoles in milk. Recoveries of fenbendazole (FBZ), oxfendazole (OFZ), and thiabendazole (T... |
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Thiabendazole and 5-hydroxythiabendazole in the plasma of sheep.
J. Vet. Pharmacol. Ther. 8(4) , 413-4, (1985)
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Simultaneous determination of thiabendazole and its major metabolite, 5-hydroxythiabendazole, in bovine tissues using gradient liquid chromatography with thermospray and atmospheric pressure chemical ionisation mass spectrometry.
J. Chromatogr. B. Biomed. Sci. Appl. 718(1) , 103-13, (1998) A novel method is presented for the determination of thiabendazole and 5-hydroxythiabendazole in animal tissues. Samples are homogenised in buffer at pH=7.0, extracted with ethyl acetate and cleaned up using CN solid-phase extraction columns. Thiabendazole an... |
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Des-tyrosine-gamma-endorphin effects on morphine analgesia in mice.
Fundam. Clin. Pharmacol. 12(2) , 225-35, (1998) 1. The effects that were induced by a beta-lipotropin fragment des-tyrosine-gamma-endorphin (DT gamma E) devoid of opiate activity that was administered intraperitoneally or intracerebroventricularly to mice under morphine analgesia were investigated. The int... |
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Determination of thiabendazole and 5-hydroxythiabendazole in human serum by fluorescence-detected high-performance liquid chromatography.
J. Chromatogr. A. 230(1) , 79-86, (1982) We have developed a rapid, sensitive and precise high-performance liquid chromatographic method using fluorescence detection for the simultaneous determination of thiabendazole and unconjugated 5-hydroxythiabendazole in serum. Sample pretreatment consists onl... |
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Liquid chromatographic fluorescence method for multiresidue determination of thiabendazole and 5-hydroxythiabendazole in milk.
J. AOAC Int. 78(3) , 642-6, (1995) A novel liquid chromatographic multiresidue method has been developed for quantitation of thiabendazole (TBZ), the metabolite 5-hydroxythiabendazole (5-OH-TBZ), and the sulfate conjugate of 5-hydroxythiabendazole (5-HSO4-TBZ) in raw cow's milk. The 5-HSO4-TBZ... |