Methyl pyruvate
Methyl pyruvate structure
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Common Name | Methyl pyruvate | ||
|---|---|---|---|---|
| CAS Number | 600-22-6 | Molecular Weight | 102.089 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 135.5±0.0 °C at 760 mmHg | |
| Molecular Formula | C4H6O3 | Melting Point | 134-137 °C | |
| MSDS | Chinese USA | Flash Point | 39.4±0.0 °C | |
| Symbol |
GHS02 |
Signal Word | Warning | |
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Mitochondrial function provides instructive signals for activation-induced B-cell fates.
Nat. Commun. 6 , 6750, (2015) During immune reactions, functionally distinct B-cell subsets are generated by stochastic processes, including class-switch recombination (CSR) and plasma cell differentiation (PCD). In this study, we show a strong association between individual B-cell fates ... |
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Oxidative damage to mitochondria at the nodes of Ranvier precedes axon degeneration in ex vivo transected axons
Exp. Neurol. 261 , 127-35, (2014) Oxidative stress and mitochondrial dysfunction appear to contribute to axon degeneration in numerous neurological disorders. However, how these two processes interact to cause axonal damage—and how this damage is initiated—remains unclear. In this study we us... |
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Calcium release channel RyR2 regulates insulin release and glucose homeostasis.
J. Clin. Invest. 125 , 1968-78, (2015) The type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic reticulum (ER) of several types of cells, including cardiomyocytes and pancreatic β cells. In cardiomyocytes, RyR2-dependent Ca2+ release is critical for excitation-contraction ... |
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Influence of pyruvic acid methyl ester on rat pancreatic islets. Effects on insulin secretion, phosphoinositide hydrolysis, and sensitization of the beta cell.
J. Biol. Chem. 272(6) , 3527-31, (1997) The methyl ester of pyruvic acid (methyl pyruvate) stimulated a dose-dependent increase in insulin secretion from isolated perifused rat islets. The threshold level for release was about 10 mM, and at 20 mM the addition of MP to perifused islets resulted in a... |
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Utility of historical vehicle-control data in the interpretation of the local lymph node assay.
Contact Dermatitis 49(1) , 37-41, (2003) The accepted approach to the interpretation of local lymph node assay (LLNA) data requires comparison of responses in the test groups with background activity found in concurrent vehicle-treated controls. However, of established value in the interpretation of... |
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Potentiation and prolongation of the insulinotropic action of glucagon-like peptide 1 by methyl pyruvate or dimethyl ester of L-glutamic acid in a type 2 diabetes animal model.
Endocrine 16(2) , 113-6, (2001) Methyl pyruvate and the dimethyl ester of L-glutamic acid were administered intravenously, as a primed constant infusion (1.0-2.0 micromol followed by 0.5-1.0 micromol/min, both expressed per gram of body wt), in adult rats that had been injected with strepto... |
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Potentiation by methyl pyruvate of GLP-1 insulinotropic action in normal rats.
Int. J. Mol. Med. 7(6) , 621-3, (2001) Methyl pyruvate (MP) stimulates insulin release both in vivo and in vitro. The present study aims at investigating whether MP is also able to enhance the B-cell secretory response to glucagon-like peptide 1 (GLP-1). In anaesthetized rats receiving a primed co... |
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Methyl pyruvate stimulates pancreatic beta-cells by a direct effect on KATP channels, and not as a mitochondrial substrate.
Biochem. J. 368(Pt 3) , 817-25, (2002) In pancreatic beta-cells, methyl pyruvate is a potent secretagogue and is widely used to study stimulus-secretion coupling. In contrast with pyruvate, which barely stimulates insulin secretion, methyl pyruvate was suggested to act as an effective mitochondria... |
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Energetic requirement of carbachol-induced Ca2+ signaling in single mouse beta-cells.
Endocrinology 141(11) , 4065-71, (2000) Insulin secretion is under multifactorial control by glucose and neurohumoral factors like acetylcholine (ACH), which activate the Ca2+/phospholipase C signaling pathway. All insulin secretagogues elevate cytosolic free Ca2+ ([Ca2+]i) that is central to the s... |
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Overexpression of short heterodimer partner recovers impaired glucose-stimulated insulin secretion of pancreatic beta-cells overexpressing UCP2.
J. Endocrinol. 183(1) , 133-44, (2004) The short heterodimer partner (SHP) (NR0B2) is an orphan nuclear receptor whose function in pancreatic beta-cells is unclear. Mitochondrial uncoupling protein (UCP2) in beta-cells is upregulated in obesity-related diabetes, causing impaired glucose-stimulated... |