4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt hydrate

4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt hydrate Structure
4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt hydrate structure
Common Name 4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt hydrate
CAS Number 207233-90-7 Molecular Weight 452.50500
Density N/A Boiling Point N/A
Molecular Formula C16H8N2O6S4 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger

Differential effects of viroporin inhibitors against feline infectious peritonitis virus serotypes I and II.

Arch. Virol. 160(5) , 1163-70, (2015)

Feline infectious peritonitis virus (FIP virus: FIPV), a feline coronavirus of the family Coronaviridae, causes a fatal disease called FIP in wild and domestic cat species. The genome of coronaviruses encodes a hydrophobic transmembrane protein, the envelope ...

Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns.

Cell Death Dis. 5 , e1494, (2014)

Apoptosis, which is anti-inflammatory, and necrosis, which is pro-inflammatory, represent the extremes of the cell death spectrum. Cell death is complex and both apoptosis and necrosis can be observed in the same cells or tissues. Here, we introduce a novel c...

Interference with distinct steps of sphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells.

Biochem. Pharmacol. 96 , 119-30, (2015)

Glioblastoma is the most common malignant brain tumor, which, despite combined radio- and chemotherapy, recurs and is invariably fatal for affected patients. Members of the sphingolipid (SL) family are potent effectors of glioma cell proliferation. In particu...

Binding of human myeloperoxidase to red blood cells: Molecular targets and biophysical consequences at the plasma membrane level.

Arch. Biochem. Biophys. 591 , 87-97, (2016)

Myeloperoxidase (MPO) is an oxidant-producing enzyme that can also bind to cellular surface proteins. We found that band 3 protein and glycophorins A and B were the key MPO-binding targets of human red blood cells (RBCs). The interaction of MPO with RBC prote...

Inhibition of VDAC1 prevents Ca²⁺-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages.

Apoptosis 19(12) , 1712-26, (2014)

Ultrasound combined with endogenous protoporphyrin IX derived from 5-aminolevulinic acid (ALA-SDT) is known to induce apoptosis in multiple cancer cells and macrophages. Persistent retention of macrophages in the plaque has been implicated in the pathophysiol...

Thrombin-facilitated efflux of D-[3H]-aspartate from cultured astrocytes and neurons under hyponatremia and chemical ischemia.

Neurochem. Res. 39(7) , 1219-31, (2014)

Thrombin effect increasing swelling-induced glutamate efflux was examined in cultured cortical astrocytes, cerebellar granule neurons (CGN), hippocampal and cortical neurons. Hypotonic glutamate efflux (monitored by D-[(3)H]aspartate) from cortical astrocytes...

Uptake of aristolochic acid I into Caco-2 cells by monocarboxylic acid transporters.

Biol. Pharm. Bull. 37(9) , 1475-9, (2014)

The uptake mechanism of aristolochic acid I (AAI) was investigated using Caco-2 cells cultured on dishes and permeable membranes. The uptake of AAI from the apical membrane of Caco-2 cells cultured on a dish was rapid, and a decrease in the pH of the incubati...

Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity.

Mol. Brain 8 , 35, (2015)

Voltage-sensitive dye (VSD) imaging and intrinsic optical signals (IOS) are widely used methods for monitoring spatiotemporal neural activity in extensive networks. In spite of that, identification of their major cellular and molecular components has not been...

Caffeine-induced diuresis and natriuresis is independent of renal tubular NHE3.

Am. J. Physiol. Renal Physiol. 308 , F1409-20, (2015)

Caffeine is one of the most widely consumed behavioral substances. We have previously shown that caffeine- and theophylline-induced inhibition of renal reabsorption causes diuresis and natriuresis, an effect that requires functional adenosine A1 receptors. In...

Abscisic acid transport in human erythrocytes.

J. Biol. Chem. 290 , 13042-52, (2015)

Abscisic acid (ABA) is a plant hormone involved in the response to environmental stress. Recently, ABA has been shown to be present and active also in mammals, where it stimulates the functional activity of innate immune cells, of mesenchymal and hemopoietic ...