N-Nitrosodibutylamine
N-Nitrosodibutylamine structure
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Common Name | N-Nitrosodibutylamine | ||
|---|---|---|---|---|
| CAS Number | 924-16-3 | Molecular Weight | 158.24100 | |
| Density | 0.91 g/cm3 | Boiling Point | 250.6ºC at 760 mmHg | |
| Molecular Formula | C8H18N2O | Melting Point | <25℃ | |
| MSDS | Chinese USA | Flash Point | 105.3ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Commercial formaldehyde standard for mass calibration in mass spectrometry.
J. Mass Spectrom. 50(3) , 463-9, (2015) Common calibration standards for mass spectrometry can be a source of many problems including instrument contamination, ionization suppression and formation of unidentified ions during subsequent analysis. In this article, we present a new approach for the ca... |
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A salting out-acetonitrile homogeneous extraction coupled with gas chromatography-mass spectrometry method for the simultaneous determination of thirteen N-nitrosamines in skin care cosmetics.
J. Chromatogr. A. 1422 , 82-8, (2015) A sensitive gas chromatography-mass spectrometry method was established for the simultaneous determination of thirteen N-nitrosamines (NAs) in skin care cosmetics. The cosmetics samples were firstly dispersed by water and subsequently extracted and purified u... |
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Cytochrome P450 hydroxylation of carbon atoms of the alkyl chain of symmetrical N-nitrosodialkylamines by human liver microsomes.
Mutat. Res. 377(2) , 199-209, (1997) A panel of 14 human liver microsomal preparations metabolized at variable rates three symmetrical nitrosodialkylamines (N-nitroso-dipropyl, dibutyl and diamyl-amines, NDPA, NDBA, NDAA) into aldehydes and hydroxynitrosamines. Formation of linear aldehydes, con... |
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Role of cytochrome P450 in DNA damage induced by N-nitrosodialkylamines in cultured rat hepatocytes.
Carcinogenesis 17(3) , 569-76, (1996) The involvement of cytochrome P450 in the cytotoxicity and DNA damage-repair induced by N-nitrosodipropylamine (NDPA), N-nitroso-n-butyl-n-propylamine (NBPA), and N-nitrosodibutylamine (NDBA) was investigated in cultured hepatocytes isolated from untreated, p... |
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Myricetin, quercetin, (+)-catechin and (-)-epicatechin protect against N-nitrosamines-induced DNA damage in human hepatoma cells.
Toxicol. In Vitro 23(7) , 1292-7, (2009) The aim of this study was to investigate the protective effect of myricetin, quercetin, (+)-catechin and (-)-epicatechin, against N-nitrosodibutylamine (NDBA) and N-nitrosopiperidine (NPIP)-induced DNA damage in human hepatoma cells (HepG2). DNA damage (stran... |
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High susceptibility of p53 knockout mice to esophageal and urinary bladder carcinogenesis induced by N, N-dibutylnitrosamine.
Cancer Lett. 194(1) , 45-54, (2003) In human cancer, alterations in the p53 tumor suppressor gene are the most common genetic alterations. The aim of the present study was to detect sensitivity of the p53 (+/-) mice and their littermates p53 (+/+) mice to N, N-dibutylnitrosamine (DBN) carcinoge... |
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Detection of mutagenicity in Ames test using a metalloporphyrin/oxidant model system for cytochrome P450.
Mutat. Res. 373(1) , 99-105, (1997) A chemical model system for cytochrome P450, a porphyrin and an oxidant, was used in Ames assay as a substitute for S9 mix. In the presence of tetrakis(pentafluorophenyl)porphyrinatoiron(III) chloride [Fe(F5P)Cl] and tert-butyl hydroperoxide (t-BuOOH), mutage... |
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Effects of butylated hydroxyanisole pretreatment on low dose N-methyl-N'-nitro-N-nitrosoguanidine- or N,N-dibutylnitrosamine-induced rat forestomach or esophageal carcinogenesis.
Carcinogenesis 12(10) , 1773-6, (1991) The effects of butylated hydroxyanisole (BHA) pretreatment on subsequent low dose N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or N,N-dibutylnitrosamine (DBN) treatment on forestomach or esophageal carcinogenesis were investigated in male F344 rats. Groups of ... |
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Volatile N-nitrosamines in selected Italian cheeses.
Bull. Environ. Contam. Toxicol. 57(1) , 16-21, (1996)
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Effects of ozonation on mutagenic activity of nitrosamines.
Bull. Environ. Contam. Toxicol. 52(5) , 681-6, (1994)
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