(D-Arg1,D-Phe5,D-Trp7.9,Leu11)-Substance P

更新时间：2024-01-02 10:59:49

(D-Arg1,D-Phe5,D-Trp7.9,Leu11)-Substance P结构式	常用名	(D-Arg1,D-Phe5,D-Trp7.9,Leu11)-Substance P	英文名	(D-Arg1,D-Phe5,D-Trp7.9,Leu11)-Substance P
	CAS号	96736-12-8	分子量	1516.831
	密度	1.4±0.1 g/cm3	沸点	N/A
	分子式	C₇₉H₁₀₉N₁₉O₁₂	熔点	N/A
	MSDS	美版	闪点	N/A

用途

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 是 P 物质的衍生物,是神经肽和趋化因子受体的偏向激动剂。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 激活 G12。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 与 IL-8 和 GRP受体结合。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 抑制 ERK-2 激活,激活 JNK 活性。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 刺激中性粒细胞迁移和 Ca2+ 动员增加。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 也是一种 bombesin 拮抗剂,并抑制小细胞肺癌的生长。

英文名	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
英文别名	更多

描述	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 是 P 物质的衍生物,是神经肽和趋化因子受体的偏向激动剂。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 激活 G12。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 与 IL-8 和 GRP受体结合。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 抑制 ERK-2 激活,激活 JNK 活性。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 刺激中性粒细胞迁移和 Ca2+ 动员增加。[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 也是一种 bombesin 拮抗剂,并抑制小细胞肺癌的生长。
相关类别	研究领域 >> 癌症信号通路 >> 免疫及炎症 >> 白细胞介素相关研究领域 >> 炎症/免疫信号通路 >> G 蛋白偶联受体/G 蛋白 >> Bombesin Receptor 信号通路 >> MAPK/ERK信号通路 >> JNK
参考文献	[1]. Jarpe MB, et al. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P acts as a biased agonist toward neuropeptide and chemokine receptors. J Biol Chem. 1998 Jan 30;273(5):3097-104. [2]. Woll PJ, Rozengurt E. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1859-63.

描述

相关类别

研究领域 >> 癌症

信号通路 >> 免疫及炎症 >> 白细胞介素相关

研究领域 >> 炎症/免疫

信号通路 >> G 蛋白偶联受体/G 蛋白 >> Bombesin Receptor

信号通路 >> MAPK/ERK信号通路 >> JNK

参考文献

[1]. Jarpe MB, et al. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P acts as a biased agonist toward neuropeptide and chemokine receptors. J Biol Chem. 1998 Jan 30;273(5):3097-104.

[2]. Woll PJ, Rozengurt E. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1859-63.

密度	1.4±0.1 g/cm3
分子式	C₇₉H₁₀₉N₁₉O₁₂
分子量	1516.831
精确质量	1515.850342
PSA	505.12000
LogP	3.94
折射率	1.677

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport

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L-Leucinamide, D-arginyl-L-prolyl-L-lysyl-L-prolyl-D-phenylalanyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-

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Substance P-[D-Arg1,D-Phe5,D-Trp7,9,Leu11]