(D-Arg1,D-Phe5,D-Trp7.9,Leu11)-Substance P
(D-Arg1,D-Phe5,D-Trp7.9,Leu11)-Substance P结构式
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常用名 | (D-Arg1,D-Phe5,D-Trp7.9,Leu11)-Substance P | 英文名 | (D-Arg1,D-Phe5,D-Trp7.9,Leu11)-Substance P |
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| CAS号 | 96736-12-8 | 分子量 | 1516.831 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C79H109N19O12 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Effect of nanoconfinement on polymer dynamics: surface layers and interphases.
PLoS ONE 9(7) , e103118, (2014) We present neutron spin echo experiments that address the much debated topic of dynamic phenomena in polymer melts that are induced by interacting with a confining surface. We find an anchored surface layer that internally is highly mobile and not glassy as h... |
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Intrarenal ghrelin receptor antagonism prevents high-fat diet-induced hypertension in male rats.
Endocrinology 155(7) , 2658-66, (2014) Excess weight gain contributes up to 65% of the risk of primary hypertension, and the increase in blood pressure in response to high-fat diet (HFD) is preceded by significant increases in renal tubular sodium (Na(+)) reabsorption. In normal rats, intrarenal g... |
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Over-expression of the truncated ghrelin receptor polypeptide attenuates the constitutive activation of phosphatidylinositol-specific phospholipase C by ghrelin receptors but has no effect on ghrelin-stimulated extracellular signal-regulated kinase 1/2 activity.
Int. J. Biochem. Cell Biol. 39(4) , 752-64, (2007) In addition to regulating growth hormone release from the pituitary, ghrelin receptors also influence cell proliferation and apoptosis. By studying mitogen-activated protein kinase activity in human embryonic kidney 293 cells over-expressing ghrelin receptors... |
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Unexpected effects of peptide and nonpeptide substance P receptor antagonists on basal prolactin and growth hormone release in vitro.
Peptides 14 , 109-115, (1993) The effect of peptide and nonpeptide substance P antagonists on prolactin (PRL) and growth hormone (GH) secretion was evaluated in three-dimensional rat anterior pituitary cell aggregates. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P inhibited basal growth hormo... |
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Stability and in vitro metabolism of the mitogenic neuropeptide antagonists [D-Arg1,D-Phe5, D-Trp7,9, Leu11]-substance P and [Arg6, D-Trp7,9, MePhe8]-substance P (6-11) characterized by high-performance liquid chromatography.
J. Pharm. Biomed. Anal. 12 , 811-819, (1994) The substance P (SP) analogues [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-SP and [Arg6, D-Trp7,9, MePhe8]-SP (6-11) (antagonists D and G, respectively) are under consideration as new anticancer drugs. In this report, the stability and in vitro metabolism of both antag... |
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[D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro.
Proc. Natl. Acad. Sci. U. S. A. 85 , 1859-1863, (1988) In the search for a more potent bombesin antagonist, we found [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P to be effective in mouse fibroblasts and to inhibit the growth of small cell lung cancer, a tumor that secretes bombesin-like peptides that may act as auto... |
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[D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P induces apoptosis in lung cancer cell lines in vitro.
Biochem. Biophys. Res. Commun. 199 , 1313, (1994) The broad spectrum antagonist [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P has been shown previously to inhibit the growth of small cell lung cancer cells both in vitro and in vivo. To elucidate further the pathways involved in the growth inhibitory actions ... |
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Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor.
Mol. Pharmacol. 70(3) , 936-46, (2006) [D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P functions as a low-potency antagonist but a high-potency full inverse agonist on the ghrelin receptor. Through a systematic deletion and substitution analysis of this peptide, the C-terminal carboxyamidated pentapepti... |
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Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats.
Am. J. Respir. Crit. Care Med. 176(8) , 805-13, (2007) Our study has shown that plasma levels of ghrelin, a stomach-derived peptide, are significantly reduced in sepsis, and that ghrelin administration improves organ blood flow via a nuclear factor (NF)-kappaB-dependent pathway. However, it remains unknown whethe... |
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Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivo.
Cancer Res. 52(16) , 4554-7, (1992) The proliferation of small cell lung cancer (SCLC) cells appears sustained by multiple autocrine and paracrine circuits involving Ca2+ mobilizing neuropeptides. Consequently, broad spectrum neuropeptide antagonists which inhibit SCLC growth in vitro have been... |