肝素钠结构式
|
常用名 | 肝素钠 | 英文名 | Heparin sodium |
---|---|---|---|---|
CAS号 | 9041-08-1 | 分子量 | 6117(Average) | |
密度 | N/A | 沸点 | N/A | |
分子式 | (C14H25NO20S3)n.xNa | 熔点 | >181°C (dec.) | |
MSDS | 美版 | 闪点 | N/A |
肝素钠用途Heparin sodium salt是一种抗凝剂,可与 抗凝血酶III (ATIII) 可逆地结合,大大加快了ATIII使凝血酶因子IIa 和 Xa 失活的速度。 |
中文名 | 肝素钠 |
---|---|
英文名 | Heparin sodium |
中文别名 | 阿地肝素钠 | 依诺肝素钠 | 肝素钠盐 | 凝血抗素 | 帕肝素钠 | 肝磷脂钠盐 | 达肝素钠 |
英文别名 | 更多 |
熔点 | >181°C (dec.) |
---|---|
分子式 | (C14H25NO20S3)n.xNa |
分子量 | 6117(Average) |
外观性状 | 固体;White to Almost white powder to crystal |
储存条件 | 密封避光,贮存于阴凉处。 |
更多 | 1. 性状:白色或类白色粉末。几乎无臭、无味、有吸湿性。 2. 溶解性:溶于水和食盐水,不溶于乙醇、丙酮、苯、氯仿和乙醚。1%水溶液pH 6.0~7.5。 |
肝素钠毒理学数据: 急性毒性: LD50(大鼠,静脉):354mg/kg 肝素钠生态学数据: 通常对水是稍微危害的,不要将未稀释或大量产品接触地下水,水道或者污水系统。若无政府许可,勿将材料排入周围环境。 |
个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
---|---|
危害码 (欧洲) | Xi |
风险声明 (欧洲) | 36/37/38-42/43 |
安全声明 (欧洲) | 22-24-26-36/37 |
危险品运输编码 | NONH for all modes of transport |
WGK德国 | 2 |
RTECS号 | MI0850000 |
海关编码 | 30019010 |
1. 肝素最初从肝脏中提出,现多由猪、羊、牛等动物的肠粘膜中提取,从肺脏,肝脏出可提取。取新鲜肠粘膜投入反应锅内,按3%加入氯化钠,用40%的氢氧化钠调节pH至9.5。在半小时内逐步升温至60-65℃,继续保温搅拌2h,然后升温至95℃,维持10min,冷却至50℃以下过滤。将强碱性季铵盐阴离子树脂加入滤液中,搅拌吸附8小时,静置过液。次日,虹吸去上层液,树脂用水冲洗至上清液澄清,滤干,用2倍量1.4M氯化钠搅拌2小时,滤干,树脂再用不着倍量1.4M氯化钠洗涤1次。然后,树脂用3M氯化钠洗脱两次,滤干,将滤液合并,加入等量的95%乙醇沉淀过液,收集沉淀,用丙酮脱水干燥,得粗制品。粗制品溶于1%氯化钠中,用盐酸调节pHGCF 1.7-1.8,过滤。用5N氢氧化钠调节pH至11,加30%浓度过氧化氢脱色,过滤。滤液用盐酸调节pH至6,加入等量95%乙醇沉淀。沉啶物用丙酮洗涤,干燥,即为肝素。
2. 酶解- 树脂法
3. 盐解- 树脂法
Paternal breed effects on expression of IGF-II, BAK1 and BCL2-L1 in bovine preimplantation embryos.
Zygote 23 , 712-21, (2015) The effects of the paternal breed on early embryo and later pre- and postnatal development are well documented. Several recent studies have suggested that such paternal effects may be mediated by the ... |
|
Isolation and culture of human oligodendrocyte precursor cells from neurospheres.
Brain Res. Bull. 118 , 17-24, (2015) Culture of human oligodendrocyte precursor cells (OPCs) can help understand the regulatory mechanism of differentiation and myelination of oligodendrocytes. However, existing culture methods have limi... |
|
Layer-by-layer assembled cell instructive nanocoatings containing platelet lysate.
Biomaterials 48 , 56-65, (2015) Great efforts have been made to introduce growth factors (GFs) onto 2D/3D constructs in order to control cell behavior. Platelet lysate (PL) presents itself as a cost-effective source of multiple GFs ... |
sodium heparinate |
Sodium 2-[3,5-bis(2-hydroxyethyl)-1,3,5-triazinan-1-yl]ethanolate |
porcine heparin sodium |
enoxaparin sodium |
1,3,5-Triazine-1,3,5(2H,4H,6H)-triethanol, sodium salt (1:1) |
bovine heparin sodium |
reviparin sodium |
hep, na, porcine |
hep, na, bovine |
MFCD00081689 |
Heparin (sodium salt) |