来普霉素A

更新时间：2024-01-11 20:59:52

来普霉素A结构式	常用名	来普霉素A	英文名	Leptomycin A
	CAS号	87081-36-5	分子量	526.70400
	密度	1.079g/cm3	沸点	717.7ºC at 760 mmHg
	分子式	C₃₂H₄₆O₆	熔点	N/A
	MSDS	美版	闪点	224.2ºC
	符号	GHS02, GHS06, GHS08	信号词	Danger

来普霉素A用途

Leptomycin A 是链霉菌的代谢物,是 CRM1 的抑制剂,阻断CRM1和核出口信号相互作用,阻止多种蛋白质的核出口。Leptomycin A 抑制 HIV-1的复制。活性略低于 Leptomycin B。

中文名	来普霉素A
英文名	leptomycin A
英文别名	更多

描述	Leptomycin A 是链霉菌的代谢物,是 CRM1 的抑制剂,阻断CRM1和核出口信号相互作用,阻止多种蛋白质的核出口。Leptomycin A 抑制 HIV-1的复制。活性略低于 Leptomycin B。
相关类别	信号通路 >> 抗感染 >> HIV 研究领域 >> 感染信号通路 >> 跨膜转运 >> CRM1
靶点	CRM1[1][2].
参考文献	[1]. Kudo, N., et al. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp. Cell Res. 242(2), 540-547 (1998). [2]. Wolff B, et al. Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem Biol. 1997 Feb;4(2):139-47.

密度	1.079g/cm3
沸点	717.7ºC at 760 mmHg
分子式	C₃₂H₄₆O₆
分子量	526.70400
闪点	224.2ºC
精确质量	526.32900
PSA	100.90000
LogP	6.39460
折射率	1.544
储存条件	?20°C

来普霉素A毒性英文版

符号	GHS02, GHS06, GHS08
信号词	Danger
危害声明	H225-H301 + H311 + H331-H370
警示性声明	P210-P260-P280-P301 + P310-P311
危害码 (欧洲)	F,T
风险声明 (欧洲)	11-23/24/25-39/23/24/25
安全声明 (欧洲)	16-36/37-45
危险品运输编码	UN 1230 3/PG 2

Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function.

Cell. Mol. Life Sci. 68 , 847-62, (2011)

The mitogen-activated protein kinase-activated protein kinase-5 (MK5) resides predominantly in the nucleus of resting cells, but p38(MAPK), extracellular signal-regulated kinases-3 and -4 (ERK3 and ER...

Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization.

J. Antibiot. 36(6) , 639-45, (1983)

A strain of Streptomyces was found to produce new antifungal antibiotics. The active compounds were purified and separated into two substances named leptomycin A and B by high performance liquid chrom...

Leptomycins A and B, new antifungal antibiotics. II. Structure elucidation.

J. Antibiot. 36(6) , 646-50, (1983)

The structures of new antifungal antibiotics, leptomycins A and B produced by Streptomyces sp. ATS1287 were determined as described below (Fig. 1) on the basis of their spectral and chemical character...

(2E,10E,12E,16E,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid

2,10,12,16,18-Nonadecapentaenoic acid,19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo

C32H46O6

2,10,12,16,18-Nonadecapentaenoic acid,19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo

Leptomycin A

Jildamycin