维那卡兰

• 常用名: 维那卡兰
• 英文名: Vernakalant
• CAS号: 794466-70-9
• 分子量: 349.464
• 密度: 1.1±0.1 g/cm3
• 沸点: 479.0±45.0 °C at 760 mmHg
• 分子式: C₂₀H₃₁NO₄
• 熔点: N/A
• 闪点: 243.5±28.7 °C

维那卡兰用途

Vernakalant(RSD-1235)是混合型离子通道阻断剂，在2到5 mg/kg剂量下，能终止急性心房颤动。

维那卡兰名称

• 中文名: 维那卡兰
• 英文名: (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol

维那卡兰生物活性

• 描述: Vernakalant(RSD-1235)是混合型离子通道阻断剂,在2到5 mg/kg剂量下,能终止急性心房颤动。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钾通道
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Dorian, Paul MD et al. The Effect of Vernakalant (RSD1235), an Investigational Antiarrhythmic Agent, on Atrial Electrophysiology in Humans. Journal of Cardiovascular Pharmacology:July 2007 - Volume 50 -Issue 1 - pp 35-40.

  [2]. Jodene Eldstrom et al. The Molecular Basis of High-Affinity Binding of the Antiarrhythmic Compound Vernakalant (RSD1235) to Kv1.5 Channels. Molecular Pharmacology December 2007 vol. 72 no. 6 1522-1534

  [3]. Vernakalant. Too dangerous in atrial fibrillation.Prescrire Int. 2012 May;21(127):119-22.

  [4]. Blomstr?m-Lundqvist C, Blomstr?m P.Safety and efficacy of pharmacological cardioversion of atrial fibrillation using intravenous vernakalant, a new antiarrhythmic drug with atrial selectivity.Expert Opin Drug Saf. 2012 Jul;11(4):671-9. Epub 2012 May 26.

  [5]. Bash LD, Buono JL, Davies GM, Martin A, Fahrbach K, Phatak H, Avetisyan R, Mwamburi M.Systematic review and meta-analysis of the efficacy of cardioversion by vernakalant and comparators in patients with atrial fibrillation.Cardiovasc Drugs Ther. 2012 Apr;

维那卡兰物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 479.0±45.0 °C at 760 mmHg
• 分子式: C₂₀H₃₁NO₄
• 分子量: 349.464
• 闪点: 243.5±28.7 °C
• 精确质量: 349.225311
• PSA: 51.16000
• LogP: 2.40
• InChIKey: VBHQKCBVWWUUKN-KZNAEPCWSA-N
• SMILES: COc1ccc(CCOC2CCCCC2N2CCC(O)C2)cc1OC
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.557
• 储存条件: 室温，干燥

维那卡兰英文别名

• (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]-3-pyrrolidinol
• (1R,2R)-2-[(3R)-hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)cyclohexane
• Kynapid
• Vernakalant
• 3-Pyrrolidinol, 1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]-, (3R)-
• Brinavess
• (1R-{2R-[2-(3,4-dimethoxyphenyl)-ethoxy]-cyclohex-2-yl})-pyrrolidin-3R-ol
• (3R)-1-{(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl}pyrrolidin-3-ol
• RSD 1235
• (3R)-1-{(1R,2R)-2-[2-(3,4-Dimethoxyphenyl)ethoxy]cyclohexyl}-3-pyrrolidinol
• 1R-(2R-(2-(3,4-dimethoxy-phenyl)-ethoxy)-cyclohexyl)-pyrrolidin-3R-ol
• Vernakalant [INN:BAN]
• UNII-9G468C8B13
• cc-484
• Vernakalant [INN]
• (3R)-1-{(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl}pyrrolidinol