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101-93-9

101-93-9结构式

常用中文名：非那卡因
常用英文名：holocalin(p)
CAS号：101-93-9
分子式：C₁₈H₂₂N₂O₂
分子量：298.37900
相关类别：天然产物生物碱
发布时间：2018-04-28 08:00:00
更新时间：2024-01-08 11:26:43
菲那卡因(Holocaine)是一种局部麻醉剂。菲那卡因抑制来自大脑和心脏的红细胞Ca2+-ATP酶和环核苷酸磷酸二酯酶的特异性钙调素依赖性刺激[1][2]。

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中文名	非那卡因
英文名	N,N'-bis(4-ethoxyphenyl)ethanimidamide
中文别名	哈樂卡因
英文别名	Fenacaine Holocaine Phenacaine Tanicaine

描述	菲那卡因(Holocaine)是一种局部麻醉剂。菲那卡因抑制来自大脑和心脏的红细胞Ca2+-ATP酶和环核苷酸磷酸二酯酶的特异性钙调素依赖性刺激[1][2]。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE) 研究领域 >> 代谢疾病
体外研究	菲那卡因抑制脑和心脏组织中红细胞Ca2+-ATP酶(EC 3.6.1.3)和环核苷酸磷酸二酯酶(EC 3.1.4.17)的特异性钙调素依赖性刺激[1]。菲那卡因(1μM-1 mM)可抑制胰腺葡萄糖诱导的胰岛素分泌[2]。

密度	1.04g/cm3
沸点	464.5ºC at 760mmHg
熔点	117°C
分子式	C₁₈H₂₂N₂O₂
分子量	298.37900
闪点	234.7ºC
精确质量	298.16800
PSA	42.85000
LogP	4.71900
蒸汽压	8.29E-09mmHg at 25°C
折射率	1.534
储存条件	库房通风低温干燥; 与食品原料分开存放
稳定性	可燃; 受热分解有毒氮氧化物烟雾,高毒
计算化学	1.疏水参数计算参考值（XlogP）:3.6 2.氢键供体数量:1 3.氢键受体数量:3 4.可旋转化学键数量:7 5.互变异构体数量:2 6.拓扑分子极性表面积42.8 7.重原子数量:22 8.表面电荷:0 9.复杂度:330 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1

毒理学数据:

腹腔-豚鼠 LDL0: 50 毫克/公斤; 静脉-豚鼠 LDL0: 15 毫克/公斤

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AD0350000

CHEMICAL NAME :: Acetamidine, N,N'-bis(p-ethoxyphenyl)-

CAS REGISTRY NUMBER :: 101-93-9

BEILSTEIN REFERENCE NO. :: 2702842

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C18-H22-N2-O2

MOLECULAR WEIGHT :: 298.42

WISWESSER LINE NOTATION :: 2OR DNUY1&MR DO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 53 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932

海关编码	2925290090

海关编码	2925290090
中文概述	2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%