骨化三醇 D6

• 常用名: 骨化三醇 D6
• 英文名: Calcitriol D6
• CAS号: 78782-99-7
• 分子量: 422.67300
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₃₈D₆O₃
• 熔点: N/A
• 闪点: 14 °C
• 符号: GHS02, GHS07
• 信号词: Danger

骨化三醇 D6用途

Calcitriol D6是骨化三醇的含重氢形式,骨化三醇是维生素D3的活性代谢物。

骨化三醇 D6名称

• 中文名: 骨化三醇 D6
• 英文名: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

骨化三醇 D6生物活性

• 描述: Calcitriol D6是骨化三醇的含重氢形式,骨化三醇是维生素D3的活性代谢物。
• 相关类别:
  信号通路 >> 维生素 D 相关 >> VD/VDR
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004)

  [2]. Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373.

  [3]. Nijenhuis et al (2006) The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 20 1589.

  [4]. Krishnan AV, Swami S, Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment and prevention.J Steroid Biochem Mol Biol. 2012 Aug 23.

  [5]. Alkharfy KM, Al-Daghri NM, Yakout SM, Ahmed M.Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes of the Liver in a Rodent Model.Basic Clin Pharmacol Toxicol. 2012 Aug 21.

骨化三醇 D6物理化学性质

• 分子式: C₂₇H₃₈D₆O₃
• 分子量: 422.67300
• 精确质量: 422.36700
• PSA: 60.69000
• LogP: 5.70470
• InChIKey: GMRQFYUYWCNGIN-CMIVPSFDSA-N
• SMILES: C=C1C(=CC=C2CCCC3(C)C2CCC3C(C)CCCC(C)(C)O)CC(O)CC1O
• 储存条件: 2-8℃

骨化三醇 D6安全信息

• 符号: GHS02, GHS07
• 信号词: Danger
• 危害声明: H225-H319
• 警示性声明: P210-P305 + P351 + P338-P370 + P378-P403 + P235
• 危险品运输编码: UN1170 - class 3 - PG 2 - Ethanol, solution
• 闪点（华氏）: 57.2 °F
• 闪点（摄氏）: 14 °C

骨化三醇 D6英文别名

• Soltriol-d6
• Rocaltrol-d6
• Topitriol-d6
• Calcijex-d6
• Silkis-d6
• Panbonis-d6
• Toptriol-d6
• Calcitriol-d6
• Calcitriol D6